Effect of a water soluble derivative of fullerene C60 on the features neural progenitor cells in vitro

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Cell and Organ Transplantology. 2013; 1(1):102-107.
DOI: 10.22494/COT.V1I1.49

Effect of a water soluble derivative of fullerene C60 on the features neural progenitor cells in vitro

Rybachuk О. А.1,2,4, Levin R. E.1,3, Кyryk V. М.2, Susarova D. K.3, Tsupykov О. M.1,2,4, Smozhanik E. G.1,4, Butenko G. M.2, Skibo G. G.1,2,4, Troshin P. A.3, Pivneva Т. А.1,2,4
1Bogomoletz Institute of Physiology NAS Ukraine, Кyiv, Ukraine
2State Institute of Genetic and Regenerative Medicine NAMS Ukraine, Kyiv, Ukraine
3Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Russia
4State Key Laboratory, Кyiv, Ukraine

We studied the effect of a water soluble derivative of fullerene C60 on the behavior of cultured neural stem/progenitor cells. Addition of 20 nM of metal fullerenolate C60 (NaFL) into the cell culture increased the population of the cells almost twice in comparison with the control and also suppressed the formation of neurospheres. The obtained data allow us to suggest that NaFL has a positive effect on the proliferative activity of neural progenitors. The water-soluble fullerene nanostructures such as NaFL promoting the proliferation of neural stem cells might have numerous beneficent applications in cell biology and biotechnology.

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Rybachuk ОА, Levin RE, Кyryk VМ, Susarova DK, Tsupykov ОM, Smozhanik E G, Butenko GM, Skibo GG, Troshin PA, Pivneva ТА. Effect of a water soluble derivative of fullerene C60 on the features neural progenitor cells in vitro. Cell and Organ Transplantology. 2013; 1(1):102-107. doi: 10.22494/COT.V1I1.49


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