Cell and Organ Transplantology. 2013; 1(1):61-65.
DOI: 10.22494/COT.V1I1.46
Cell technologies in reproductology, obstetrics and gynecology
Nasadyuk C. M.
Institute of Cell Therapy, Кyiv, Ukraine
Abstract
The review describes the current trends of the development of cell and gene technologies in obstetrics, gynecology and reproductive medicine. The strategies of allogeneic and autologous hematopoietic stem cell transplantation in the myeloablative treatment of germinal tumors and breast cancer are considered, as well as adoptive immunotherapy, modern approaches to the treatment of female and male infertility, and also prenatal cell and gene therapy. The problems and achievements in uterus transplantation are described, as well as the successes in the cryopreservation of reproductive cells and tissues.
1. Akar M, Ozkan O, Erdogan O, et al. Uterus transplantation from a deceased donor. Fertil Steril. 2013. http://www.ncbi.nlm.nih.gov/pubmed/23880349. | ||||
2. Baughman J, Geijsen N. In vitro generation of germ cells: new techniques to solve current issues. Ann NY Acad Sci. 2005; 1061:33-40. https://doi.org/10.1196/annals.1336.005 PMid:16467255 |
||||
3. Binart N, Sauvat F. Cryopreserved ovaries: models of experimental grafting. Biol Aujourdhui. 2011; 205(4):235–43. https://doi.org/10.1051/jbio/2011019 PMid:22251858 |
||||
4. Bukovsky A, Copas P, Virant-Klun I. Potential new strategies for the treatment of ovarian infertility and degenerative diseases with autologous ovarian stem cells. Expert Opin Biol Ther. 2006; 6(4):341-65. https://doi.org/10.1517/14712598.6.4.341 PMid:16548762 |
||||
5. Cervelloґ I, Gil-Sanchis C, Aymara Mas et al. Human Endometrial Side Population Cells Exhibit Genotypic, Phenotypic and Functional Features of Somatic Stem Cells. PLoS One. 2010; 5(6):1–15. https://doi.org/10.1371/journal.pone.0010964 |
||||
6. Chao K, Yang H, Chen M. Human umbilical cord mesenchymal stem cells suppress breast cancer tumourigenesis through direct cell-cell contact and internalization. J Cell Mol Med. 2012; 16(8):1803–15. https://doi.org/10.1111/j.1582-4934.2011.01459.x PMid:21973190 PMCid:PMC3822693 |
||||
7. Conese M, Ascenzioni F, Boyd A, et al. Gene and cell therapy for cystic fibrosis: from bench to bedside. J. Cyst. Fibros. – 2011. – 10, suppl 2:114 – 128. | ||||
8. David AL, Waddington SN. Candidate diseases for prenatal gene therapy. Methods Mol Biol. 2012; 891:9-39. https://doi.org/10.1007/978-1-61779-873-3_2 |
||||
9. Demirer T, Barkholt L, Blaise D, et al. Transplantation of allogeneic hematopoietic stem cells: an emerging treatment modality for solid tumors. Nat Clin Pract Oncol. 2008; 5(5):256-67. https://doi.org/10.1038/ncponc1104 PMid:18398414 |
||||
10. Díaz-García C, Akhi S, Wallin A, et al. First report on fertility after allogeneic uterus transplantation. Acta Obstet Gynecol Scand. 2010; 89(11):1491-4. https://doi.org/10.3109/00016349.2010.520688 PMid:20879912 |
||||
11. Du H, Taylor H. Stem cells and reproduction. Curr Opin Obstet Gynecol. 2010; 22(3):235-41. https://doi.org/10.1097/GCO.0b013e328338c152 PMid:20305558 PMCid:PMC3107846 |
||||
12. Dunlop C, Telfer E, Anderson R. Ovarian stem cells – potential roles in infertility treatment and fertility preservation. Maturitas. 2013. https://doi.org/10.1016/j.maturitas.2013.04.017 PMid:23693139 |
||||
13. Easley C., Simerly C, Schatten G. Stem cell therapeutic possibilities: future therapeutic options for male-factor and female-factor infertility?. Reprod Biomed Online. 2013; 27(1):75-80. https://doi.org/10.1016/j.rbmo.2013.03.003 PMid:23664220 PMCid:PMC3703485 |
||||
14. Fageeh W, Raffa H, Jabbad H, et al. Transplantation of the human uterus. Int J Gynaecol Obstet. 2002; 76(3):245-51. https://doi.org/10.1016/S0020-7292(01)00597-5 |
||||
15. Fish J. Fertility preservation for adolescent women with cancer. Adolesc Med State Art Rev. 2012; 23(1):111-22. PMid:22764558 |
||||
16. Fridriksdottir A, Petersen O., Rønnov-Jessen L. Mammary gland stem cells: current status and future challenges. Int J Dev Biol. 2011; 55(7–9):719-29. https://doi.org/10.1387/ijdb.113373af PMid:22161829 |
||||
17. Gargett CE, Masuda H. Adult Stem Cells in the Endometrium. Mol Hum Reprod. 2010; 16(11):818-834. https://doi.org/10.1093/molehr/gaq061 PMid:20627991 |
||||
18. Gray F., Turner C, Ahmed A, et al. Prenatal tracheal reconstruction with a hybrid amniotic mesenchymal stem cells-engineered construct derived from decellularized airway. J Pediatr Surg. 2012; 47(6):1072–9. https://doi.org/10.1016/j.jpedsurg.2012.03.006 PMid:22703772 |
||||
19. Hartmann K, Raabe O, Wenisch S, et al. Amniotic fluid derived stem cells give rise to neuron-like cells without a further differentiation potential into retina-like cells. Am J Stem Cells. 2013; 2(2):108-18. PMid:23862099 PMCid:PMC3708508 |
||||
20. Hu W, Wang J, He X, et al. Human umbilical blood mononuclear cell-derived mesenchymal stem cells serve as interleukin-21 gene delivery vehicles for epithelial ovarian cancer therapy in nude mice. Biotechnol Appl Biochem. 2011; 58(6):397–404. https://doi.org/10.1002/bab.63 PMid:22172102 |
||||
21. Johnson J, Bagley J, Skaznik-Wikiel M, et al. Oocyte generation in adult mammalian ovaries by putative germ cells in bone marrow and peripheral blood. Cell. 2005; 122:303–15. https://doi.org/10.1016/j.cell.2005.06.031 PMid:16051153 |
||||
22. Johnson J, Canning J, Kaneko T, et al. Germline stem cells and follicular renewal in the postnatal mammalian ovary. Nature. 2004; 428:145-50. https://doi.org/10.1038/nature02316 PMid:15014492 |
||||
23. Kang N.H, Yi B.R, Lim S.Y, et al. Human amniotic membrane-derived epithelial stem cells display anticancer activity in BALB/c female nude mice bearing disseminated breast cancer xenografts. Int J Oncol. 2012. 40(6):2022–8. PMid:22344679 |
||||
24. Kisu I, Banno K, Mihara M, et al. Current status of uterus transplantation in primates and issues for clinical application. Fertil Steril. 2013; 100(1):280–94. https://doi.org/10.1016/j.fertnstert.2013.03.004 PMid:23557761 |
||||
25. Kisu I, Mihara M, Banno K, et al. Risks for Donors in Uterus Transplantation. Reprod Sci. 2013. http://www.ncbi.nlm.nih.gov/pubmed/23793471. | ||||
26. Krotz SP, Robins JC, Ferruccio TM, et al. In vitro maturation of oocytes via the pre-fabricated self-assembled artificial human ovary. J Assist Reprod Genet. 2010; 27(12):743-50. https://doi.org/10.1007/s10815-010-9468-6 PMid:20737203 PMCid:PMC2997950 |
||||
27. Lee HJ, Selesniemi K, Niikura Y, et al. Bone marrow transplantation generates immature oocytes and rescues long-term fertility in a preclinical mouse model of chemotherapy-induced premature ovarian failure. J. Clin. Oncol. 2007; 25(22):3198-204. https://doi.org/10.1200/JCO.2006.10.3028 PMid:17664466 |
||||
28. Li P, Hu H, Yang S, et al. Differentiation of induced pluripotent stem cells into male germ cells in vitro through embryoid body formation and retinoic acid or testosterone induction. Biomed Res Int. – 2013. http://www.ncbi.nlm.nih.gov/pubmed/23509752. | ||||
29. Maggiulli R, Neri Q, Monahan D, et al. What to do when ICSI fails. Syst Biol Reprod Med. 2010; 56(5):376–87. https://doi.org/10.3109/19396361003770321 PMid:20849223 |
||||
30. Mátrai Z, Pesthy P, Gulyás G, et al. Autologous fat transplantation in the modern reconstructive surgery of breast cancer. Orv Hetil. 2012; 153(46):1816–31. https://doi.org/10.1556/OH.2012.29487 PMid:23146782 |
||||
31. Möbus V, Wandt H, Frickhofen N, et al. Phase III trial of high-dose sequential chemotherapy with peripheral blood stem cell support compared with standard dose chemotherapy for first-line treatment of advanced ovarian cancer: intergroup trial of the AGO-Ovar/AIO and EBMT. J Clin Oncol. 2007; 25(27):4187–93. https://doi.org/10.1200/JCO.2006.09.7527 PMid:17698804 |
||||
32. Müller A. Keller K, Wacker J, et al. Retransplantation of cryopreserved ovarian tissue: the first live birth in Germany. Dtsch Arztebl Int. 2012; 109(1-2):8–13. PMid:22282711 PMCid:PMC3265981 |
||||
33. Nabhan S., Bitencourt M, Duval M, et al. Fertility recovery and pregnancy after allogeneic hematopoietic stem cell transplantation in Fanconi anemia patients. Haematologica. 2010; 95(10):1783-7. https://doi.org/10.3324/haematol.2010.023929 PMid:20494929 PMCid:PMC2948106 |
||||
34. Conti M, Giudice L. From stem cells to germ cells and back again. Nature medicine. 2008; 14(11):1188–90. https://doi.org/10.1038/nm1108-1188 PMid:18989302 |
||||
35. Oktem O, Oktay K. Stem cells: a perspective on oocytes. Ann NY Acad Sci. 2008; 1127:20-6. https://doi.org/10.1196/annals.1434.010 PMid:18443325 |
||||
36. Pedrazzoli P, Martinelli G. Proceedings of the 36th annual Meeting of the European Group for Blood and Marrow Transplantation. 2010 March 21-24. Vienna, Austria. NPG. 2010. | ||||
37. Pedrazzoli P, Rosti G, Secondino S et al. High-dose chemotherapy with autologous hematopoietic stem cell support for solid tumors in adults. Semin Hematol. 2007; 44(4):286–95. https://doi.org/10.1053/j.seminhematol.2007.08.009 PMid:17961729 |
||||
38. Perillo A, Bonanno G, Pierelli L, et al. Stem cells in gynecology and obstetrics. Panminerva Med. 2004; 46(1):49-59. PMid:15238881 |
||||
39. Perillo A, Ferrandina G, Pierelli L, et al. Stem cell-based treatments for gynecological solid tumors. Eur Rev Med Pharmacol Sci. 2005; 9(2):93-102. PMid:15945498 |
||||
40. Perillo A, Pierelli L, Scambia G, et al. The role of hematopoietic stem cells in the treatment of ovarian cancer. Panminerva Med. 2002; 44(3):197–204. PMid:12094133 |
||||
41. Poirot C, Schubert B. Fertility preservation in prepubertal children. Bull Cancer. 2011; 98(5):489–99. PMid:21609893 |
||||
42. Poirot , Abirached F, Prades M, et al. Induction of puberty by autograft of cryopreserved ovarian tissue. Lancet. 2012; 379:588. https://doi.org/10.1016/S0140-6736(11)61781-9 |
||||
43. Ringdén O. Immunotherapy by allogeneic stem cell transplantation. Adv Cancer Res. 2007; 97:25–60. https://doi.org/10.1016/S0065-230X(06)97002-X |
||||
44. Roybal J, Laje P, Vrecenak J, et al. Use of manipulated stem cells for prenatal therapy. Methods Mol Biol. 2012; 891:169–81. https://doi.org/10.1007/978-1-61779-873-3_8 |
||||
45. Sun M, Wang S, Li Y, et al. Adipose-derived stem cells improved mouse ovary function after chemotherapy-induced ovary failure. Stem Cell Res Ther. 2013; 4(4):80. https://doi.org/10.1186/scrt231 PMid:23838374 PMCid:PMC3854877 |
||||
46. Surbek D, Gratwohl A, Holzgreve W. In utero hematopoietic stem cell transfer: current status and future strategies. Eur J Obstet Gynecol Reprod Biol. 1999; 85(1):109–15. https://doi.org/10.1016/S0301-2115(98)00293-0 |
||||
47. Surbek D, Holzgreve W. Prenatal stem cell transplantation: from bench to bedside. Ther Umsch. – 2002; 59(11):619–23. https://doi.org/10.1024/0040-5930.59.11.619 PMid:12498056 |
||||
48. Surbek D, Holzgreve W, Nicolaides K. Haematopoietic stem cell transplantation and gene therapy in the fetus: ready for clinical use?. Hum Reprod Update. 2001; 7(1):85–91. https://doi.org/10.1093/humupd/7.1.085 PMid:11212081 |
||||
49. Yang R, Xiong C. Application prospect of adult stem cells in male infertility. Zhonghua Nan Ke Xue. 2013; 19(5):468–71. PMid:23757975 |
Nasadyuk CM. Cell technologies in reproductology, obstetrics and gynecology. Cell and Organ Transplantology. 2013; 1(1):61-65. doi: 10.22494/COT.V1I1.46
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