Comparative analysis of clinical outcomes following regenerative injection therapy with autologous platelet concentrates in patients with partial rotator cuff tears

ORIGINAL RESEARCH

Cell and Organ Transplantology. 2026; 14(1):e2026141187.
DOI: 10.22494/cot.v14-1.187

Comparative analysis of clinical outcomes following regenerative injection therapy with autologous platelet concentrates in patients with partial rotator cuff tears

Strafun S., Holiuk Ye., Magomedov S., Sokolov I., Maslova T., Ivanova O.

National Institute of Traumatology and Orthopedics, National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine

Abstract

In recent decades, there has been a growing interest in the use of stem cells and other biotechnological products aimed at enhancing tendon and tendon-bone junction repair and regeneration.
Aim. To compare the clinical efficacy of platelet-rich plasma (PRP) and platelet lysate in patients with partial rotator cuff tears of the shoulder.
Materials and methods. This study analyzed clinical outcomes of regenerative injection therapy in 73 patients with shoulder pathology associated with partial rotator cuff tears. Depending on the type of biotechnological product used, patients were divided into two groups: Group 1 (n = 29) received intra-articular injection of leukocyte-poor platelet-rich plasma (LP-PRP), and Group 2 (n = 44) – platelet lysate. Diagnosis and confirmation of rotator cuff pathology were based on magnetic resonance imaging (MRI). Ultrasound guidance was used for the injection of the biotechnological products. Clinical outcomes and quality of life were assessed using the UCLA Shoulder Score, Oxford Shoulder Score (OSS), and the Visual Analogue Scale (VAS). Evaluations were performed before treatment and at 3, 6, and 12 months after treatment.
Results. The analysis demonstrated a significant improvement in function and pain reduction as early as 3 months after treatment with autologous platelet concentrates (platelet lysate and LP-PRP) in patients with partial rotator cuff tears (p < 0.05) according to the UCLA, OSS, and VAS scales. At 12 months, clinical outcomes were significantly better in the group treated with regenerative injection therapy using platelet lysate compared with the LP-PRP group, as reflected by UCLA, OSS, and VAS scores (p < 0.05).
Conclusions. Platelet lysate demonstrated advantages over leukocyte-poor platelet-rich plasma in terms of long-term pain relief and functional recovery of the shoulder joint over a 12-month follow-up period after treatment.

Keywords: regenerative injection therapy; shoulder joint; rotator cuff tear; autologous platelet concentrates; platelet-rich plasma; platelet lysate

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How to cite

Strafun S, Holiuk Ye, Magomedov S, Sokolov I, Maslova T, Ivanova O. Comparative analysis of clinical outcomes following regenerative injection therapy with autologous platelet concentrates in patients with partial rotator cuff tears. Cell Organ Transpl. 2026; 14(1):e2026141187. doi: https://doi.org/10.22494/cot.v14-1.187

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