Neural stem cell niches in the adult mammalian brain

Home/2015, Vol. 3, No. 2/Neural stem cell niches in the adult mammalian brain

Cell and Organ Transplantology. 2015; 3(2): 190-194.
DOI: 10.22494/COT.V3I2.13

Neural stem cell niches in the adult mammalian brain

Tsupykov O. M.
Bogomoletz Institute of Physiology NAS of Ukraine, Кyiv, Ukraine
State Institute of Genetic and Regenerative Medicine NAMS of Ukraine, Kyiv, Ukraine

Stem cells of the central nervous system have received a great deal of attention in neurobiology in the last decade.  It has been shown that neurogenesis occurs in the postnatal period in specialized niches of the adult mammalian brain. The niche is a key regulator of stem cell behavior. Recent data underscore the complexity and heterogeneity of the different components of the niche, and the presence of local signaling microdomain. The review is devoted to recent views on the structural organization of neurogenic niches and regulatory factors involved at different stages of neurogenesis in the postnatal period. Understanding of stem cells behavior in the niches can serve as a basis for determination of these cells function in the adult brain.

Key words: neural progenitors, neurovascular niche, subventricular zone, subgranular zone

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Tsupykov OM. Neural stem cell niches in the adult mammalian brain. Cell and Organ Transplantology. 2015; 3(2):190-194. doi: 10.22494/COT.V3I2.13


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