Stem cells transplantation in the treatment of patients with cerebral palsy

Cell and Organ Transplantology. 2020; 8(1):76-80.
DOI: 10.22494/cot.v8i1.107

Stem cells transplantation in the treatment of patients with cerebral palsy

Petriv T.^1,2,3, Tatarchuk M.¹, Tsymbaliuk Ya.¹, Tsymbaliuk Yu.¹, Tsymbaliuk V.⁴

¹Romodanov State Institute of Neurosurgery of the National Academy of Medical Sciences of Ukraine, Department of Reconstructive Neurosurgery with X-ray surgery, Kyiv, Ukraine
²Medical Center Hemafund, LTD, Kyiv, Ukraine
³QR Health Solutions, Kyiv, Ukraine
⁴National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine

Abstract

Cerebral palsy remains a significant problem today, despite scientific and technological progress. The high degree of disability and unsatisfactory quality of life of patients in this category, necessitates the search for and implementation of the latest treatments, one of which is cell transplantation. The use of regenerative cell technologies in the treatment of patients with cerebral palsy is extremely promising. Numerous experimental studies have significantly expanded the understanding of the mechanisms of the effect of the use of stem cells in cerebral palsy. Clinical applications of stem cells of different origins are safe, which is one of the prerequisites for continuing research in this area.
This review is devoted to the use of regenerative cell technologies in the treatment of cerebral palsy, the current state and prospects of the approach to the treatment of cerebral palsy with stem cells.

Key words: stem cells, cell therapy, cerebral palsy

Full Text PDF (eng) Full Text PDF (ua)

References

1. Nakaz MOZ №286 vid 09.04.2013р. “Pro zatverdzhennya ta vprovadzhennya mediko-tekhnologіchnih dokumentіv zі standartizacії medichnoї dopomogi pri organіchnih urazhennyah golovnogo mozku u dіtej, yakі suprovodzhuyut’sya ruhovimi porushennyami” [in Ukrainian].

2. Kabacij M. S. Goshko V. Yu.; Seker T. M. Likuvannya spasty’chny’x form dy’tyachogo cerebral’nogo paralichu v ditej na etapax operaty’vnogo vtruchannya. Travma 2016; 17 (3): 166-168. doi:10.22141/1608-1706.3.17.2016.75803 [in Ukrainian]. https://doi.org/10.22141/1608-1706.3.17.2016.75803

3. Gulati S, Sondhi V. Cerebral Palsy: An Overview. Indian J Pediatr. 2018;85(11):1006-1016. doi:10.1007/s12098-017-2475-1. https://doi.org/10.1007/s12098-017-2475-1 PMid:29152685

4. Lee FK, Lin YL, Wang PH. Mesenchymal stem cells and cerebral palsy. J Chin Med Assoc. 2020;83(4):323-324. doi:10.1097/JCMA.0000000000000263. https://doi.org/10.1097/JCMA.0000000000000263 PMid:31985567

5. Fu X, Hua R, Wang X, et al. Synergistic Improvement in Children with Cerebral Palsy Who Underwent Double-Course Human Wharton’s Jelly Stem Cell Transplantation. Stem Cells Int. 2019;2019:7481069. doi:10.1155/2019/7481069. https://doi.org/10.1155/2019/7481069 PMid:31636676 PMCid:PMC6766101

6. Boruczkowski D, Zdolińska-Malinowska I. Wharton’s Jelly Mesenchymal Stem Cell Administration Improves Quality of Life and Self-Sufficiency in Children with Cerebral Palsy: Results from a Retrospective Study. Stem Cells Int. 2019;2019:7402151. doi:10.1155/2019/7402151. https://doi.org/10.1155/2019/7402151 PMid:31191683 PMCid:PMC6525822

7. Nitkin CR, Rajasingh J, Pisano C, Besner GE, Thébaud B, Sampath V. Stem cell therapy for preventing neonatal diseases in the 21st century: Current understanding and challenges. Pediatr Res. 2020;87(2):265-276. doi:10.1038/s41390-019-0425-5. https://doi.org/10.1038/s41390-019-0425-5 PMid:31086355 PMCid:PMC6854309

8. Chang YS, Ahn SY, Sung S, Park WS. Stem Cell Therapy for Neonatal Disorders: Prospects and Challenges. Yonsei Med J. 2017;58(2):266-271. doi:10.3349/ymj.2017.58.2.266. https://doi.org/10.3349/ymj.2017.58.2.266 PMid:28120555 PMCid:PMC5290004

9. Domenighetti AA, Mathewson MA, Pichika R, et al. Loss of myogenic potential and fusion capacity of muscle stem cells isolated from contractured muscle in children with cerebral palsy. Am J Physiol Cell Physiol. 2018;315(2):C247-C257. doi:10.1152/ajpcell.00351.2017. https://doi.org/10.1152/ajpcell.00351.2017 PMid:29694232 PMCid:PMC6139501

10. Zakrzewski W, Dobrzyński M, Szymonowicz M, Rybak Z. Stem cells: past, present, and future. Stem Cell Res Ther. 2019;10(1):68. Published 2019 Feb 26. doi:10.1186/s13287-019-1165-5. https://doi.org/10.1186/s13287-019-1165-5 PMid:30808416 PMCid:PMC6390367

11. Suman S, Domingues A, Ratajczak J, Ratajczak MZ. Potential Clinical Applications of Stem Cells in Regenerative Medicine. Adv Exp Med Biol. 2019;1201:1-22. doi:10.1007/978-3-030-31206-0_1. https://doi.org/10.1007/978-3-030-31206-0_1 PMid:31898779

12. Laplane L, Solary E. Towards a classification of stem cells. Elife. 2019;8:e46563. doi:10.7554/eLife.46563 https://doi.org/10.7554/eLife.46563 PMid:30864951 PMCid:PMC6415933

13. Rameshwar P, Moore CA, Shah NN, Smith CP. An Update on the Therapeutic Potential of Stem Cells. Methods Mol Biol. 2018;1842:3-27. doi:10.1007/978-1-4939-8697-2_1. https://doi.org/10.1007/978-1-4939-8697-2_1 PMid:30196398

14. Viswanathan S, Shi Y, Galipeau J, et al. Mesenchymal stem versus stromal cells: International Society for Cell & Gene Therapy (ISCT®) Mesenchymal Stromal Cell committee position statement on nomenclature. Cytotherapy. 2019;21(10):1019-1024. doi:10.1016/j.jcyt.2019.08.002 https://doi.org/10.1016/j.jcyt.2019.08.002 PMid:31526643

15. Pіchkur L.D. Nejrohіrurgіchne lіkuvannya hvorih na dityachij cerebral’nij paralіch [disertacіya]. Kiїv (Ukraїna): DU “Іnstitut nejrohіrurgії іm. akad. A.P.Romodanova NAMN Ukraїni”; 2009 [in Ukrainian].

16. Ben-David U, Benvenisty N. The tumorigenicity of human embryonic and induced pluripotent stem cells. Nat Rev Cancer. 2011;11(4):268-277. doi:10.1038/nrc3034. https://doi.org/10.1038/nrc3034 PMid:21390058

17. Takahashi K, Tanabe K, Ohnuki M, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 2007;131(5):861-872. doi:10.1016/j.cell.2007.11.019. https://doi.org/10.1016/j.cell.2007.11.019 PMid:18035408

18. Godini R, Lafta HY, Fallahi H. Epigenetic modifications in the embryonic and induced pluripotent stem cells. Gene Expr Patterns. 2018;29:1-9. doi:10.1016/j.gep.2018.04.001. https://doi.org/10.1016/j.gep.2018.04.001 PMid:29625185

19. Berglund S, Magalhaes I, Gaballa A, Vanherberghen B, Uhlin M. Advances in umbilical cord blood cell therapy: the present and the future. Expert Opin Biol Ther. 2017;17(6):691-699. doi:10.1080/14712598.2017.1316713. https://doi.org/10.1080/14712598.2017.1316713 PMid:28379044

20. Ruggeri A, Paviglianiti A, Gluckman E, Rocha V. Impact of HLA in cord blood transplantation outcomes. HLA. 2016;87(6):413-421. doi:10.1111/tan.12792. https://doi.org/10.1111/tan.12792 PMid:27060588

21. Cavusoglu T, Kilic KD, Yigitturk G, Tomruk C, Turgut M, Uyanikgil Y. Clinical Use and Patentability of Cord Blood. Recent Pat Endocr Metab Immune Drug Discov. 2017;11(1):13-21. doi:10.2174/1872214812666180314121241. https://doi.org/10.2174/1872214812666180314121241 PMid:29542426

22. Polymeri A, Giannobile WV, Kaigler D. Bone Marrow Stromal Stem Cells in Tissue Engineering and Regenerative Medicine. Horm Metab Res. 2016;48(11):700-713. doi:10.1055/s-0042-118458. https://doi.org/10.1055/s-0042-118458 PMid:27871114

23. Lagarkova MA. Such Various Stem Cells. Biochemistry (Mosc). 2019;84(3):187-189. doi:10.1134/S0006297919030015. https://doi.org/10.1134/S0006297919030015 PMid:31221057

24. Galipeau J, Sensébé L. Mesenchymal Stromal Cells: Clinical Challenges and Therapeutic Opportunities. Cell Stem Cell. 2018;22(6):824-833. doi:10.1016/j.stem.2018.05.004. https://doi.org/10.1016/j.stem.2018.05.004 PMid:29859173 PMCid:PMC6434696

25. Fu X, Liu G, Halim A, Ju Y, Luo Q, Song AG. Mesenchymal Stem Cell Migration and Tissue Repair. Cells. 2019;8(8):784. doi:10.3390/cells8080784. https://doi.org/10.3390/cells8080784 PMid:31357692 PMCid:PMC6721499

26. Guadix JA, Zugaza JL, Gálvez-Martín P. Characteristics, applications and prospects of mesenchymal stem cells in cell therapy. Características, aplicaciones y perspectivas de las células madre mesenquimales en terapia celular. Med Clin (Barc). 2017;148(9):408-414. doi:10.1016/j.medcli.2016.11.033. https://doi.org/10.1016/j.medcli.2016.11.033 PMid:28126234

27. Marofi F, Vahedi G, Hasanzadeh A, et al. Mesenchymal stem cells as the game-changing tools in the treatment of various organs disorders: Mirage or reality? J Cell Physiol. 2019;234(2):1268-1288. doi:10.1002/jcp.27152. https://doi.org/10.1002/jcp.27152 PMid:30191962

28. Shigemoto-Mogami Y, Hoshikawa K, Goldman JE, Sekino Y, Sato K. Microglia enhance neurogenesis and oligodendrogenesis in the early postnatal subventricular zone. J Neurosci. 2014;34(6):2231-2243. doi:10.1523/JNEUROSCI.1619-13.2014. https://doi.org/10.1523/JNEUROSCI.1619-13.2014 PMid:24501362 PMCid:PMC3913870

29. Liu JA, Cheung M. Neural crest stem cells and their potential therapeutic applications. Dev Biol. 2016;419(2):199-216. doi:10.1016/j.ydbio.2016.09.006. https://doi.org/10.1016/j.ydbio.2016.09.006 PMid:27640086

30. Kosykh A, Beilin A, Sukhinich K, Vorotelyak E. Postnatal neural crest stem cells from hair follicle interact with nerve tissue in vitro and in vivo. Tissue Cell. 2018;54:94-104. doi:10.1016/j.tice.2018.08.005. https://doi.org/10.1016/j.tice.2018.08.005 PMid:30309515

31. Hofer HR, Tuan RS. Secreted trophic factors of mesenchymal stem cells support neurovascular and musculoskeletal therapies. Stem Cell Res Ther. 2016;7(1):131. doi:10.1186/s13287-016-0394-0 https://doi.org/10.1186/s13287-016-0394-0 PMid:27612948 PMCid:PMC5016979

32. Wang S, Zhu R, Li H, Li J, Han Q, Zhao RC. Mesenchymal stem cells and immune disorders: from basic science to clinical transition. Front Med. 2019;13(2):138-151. doi:10.1007/s11684-018-0627-y. https://doi.org/10.1007/s11684-018-0627-y PMid:30062557

33. Fu Y, Karbaat L, Wu L, Leijten J, Both SK, Karperien M. Trophic Effects of Mesenchymal Stem Cells in Tissue Regeneration. Tissue Eng Part B Rev. 2017;23(6):515-528. doi:10.1089/ten.TEB.2016.0365. https://doi.org/10.1089/ten.teb.2016.0365 PMid:28490258

34. Abbaspanah B, Momeni M, Ebrahimi M, Mousavi SH. Advances in perinatal stem cells research: a precious cell source for clinical applications. Regen Med. 2018;13(5):595-610. doi:10.2217/rme-2018-0019 https://doi.org/10.2217/rme-2018-0019 PMid:30129876

35. Ma T, Wang X, Jiang D. Immune Tolerance of Mesenchymal Stem Cells and Induction of Skin Allograft Tolerance. Curr Stem Cell Res Ther. 2017;12(5):409-415. doi:10.2174/1574888X12666170301122744. https://doi.org/10.2174/1574888X12666170301122744 PMid:28260519

36. Chirba MA, Sweetapple B, Hannon CP, Anderson JA. FDA regulation of adult stem cell therapies as used in sports medicine. J Knee Surg. 2015;28(1):55-62. doi:10.1055/s-0034-1398470. https://doi.org/10.1055/s-0034-1398470 PMid:25603042

37. Wang Y, Tian M, Wang F, et al. Understanding the Immunological Mechanisms of Mesenchymal Stem Cells in Allogeneic Transplantation: From the Aspect of Major Histocompatibility Complex Class I. Stem Cells Dev. 2019;28(17):1141-1150. doi:10.1089/scd.2018.0256. https://doi.org/10.1089/scd.2018.0256 PMid:31215341

38. Li N, Hua J. Interactions between mesenchymal stem cells and the immune system. Cell Mol Life Sci. 2017;74(13):2345-2360. doi:10.1007/s00018-017-2473-5. https://doi.org/10.1007/s00018-017-2473-5 PMid:28214990

39. Kiaie N, Aghdam RM, Tafti SHA, Gorabi AM. Stem Cell-Mediated Angiogenesis in Tissue Engineering Constructs. Curr Stem Cell Res Ther. 2019;14(3):249-258. doi:10.2174/1574888X13666181105145144. https://doi.org/10.2174/1574888X13666181105145144 PMid:30394215

40. Munir H, Ward LSC, McGettrick HM. Mesenchymal Stem Cells as Endogenous Regulators of Inflammation. Adv Exp Med Biol. 2018;1060:73-98. doi:10.1007/978-3-319-78127-3_5. https://doi.org/10.1007/978-3-319-78127-3_5 PMid:30155623

41. Ko HR, Ahn SY, Chang YS, et al. Human UCB-MSCs treatment upon intraventricular hemorrhage contributes to attenuate hippocampal neuron loss and circuit damage through BDNF-CREB signaling. Stem Cell Res Ther. 2018;9(1):326. doi:10.1186/s13287-018-1052-5. https://doi.org/10.1186/s13287-018-1052-5 PMid:30463591 PMCid:PMC6249960

42. Gobshtis N, Tfilin M, Wolfson M, Fraifeld VE, Turgeman G. Transplantation of mesenchymal stem cells reverses behavioural deficits and impaired neurogenesis caused by prenatal exposure to valproic acid. Oncotarget. 2017;8(11):17443-17452. doi:10.18632/oncotarget.15245. https://doi.org/10.18632/oncotarget.15245 PMid:28407680 PMCid:PMC5392261

43. Yarmolyuk E.S. Vpliv tkaninnoї transplantacії na angіogenez v dіlyancі іshemіchnogo ushkodzhennya golovnogo mozku v eksperimentі [disertacіya]. Kiїv (Ukraїna): Іnstitut nejrohіrurgії іm. akad. A. P. Romodanova NAMN Ukraїni; 2016 [in Ukrainian].

44. Gu J, Huang L, Zhang C, et al. Therapeutic evidence of umbilical cord-derived mesenchymal stem cell transplantation for cerebral palsy: a randomized, controlled trial. Stem Cell Res Ther. 2020;11(1):43. Published 2020 Feb 3. doi:10.1186/s13287-019-1545-x. https://doi.org/10.1186/s13287-019-1545-x PMid:32014055 PMCid:PMC6998370

45. Elgaz S, Kuçi Z, Kuçi S, Bönig H, Bader P. Clinical Use of Mesenchymal Stromal Cells in the Treatment of Acute Graft-versus-Host Disease. Transfus Med Hemother. 2019;46(1):27-34. doi:10.1159/000496809. https://doi.org/10.1159/000496809 PMid:31244579 PMCid:PMC6558336

46. Xie B, Chen M, Hu R, Han W, Ding S. Therapeutic Evidence of Human Mesenchymal Stem Cell Transplantation for Cerebral Palsy: A Meta-Analysis of Randomized Controlled Trials. Stem Cells Int. 2020;2020:5701920. doi:10.1155/2020/5701920/ https://doi.org/10.1155/2020/5701920 PMid:32765613 PMCid:PMC7387980

47. Wang X, Hu H, Hua R, et al. Effect of umbilical cord mesenchymal stromal cells on motor functions of identical twins with cerebral palsy: pilot study on the correlation of efficacy and hereditary factors. Cytotherapy. 2015;17(2):224-231. doi:10.1016/j.jcyt.2014.09.010/ https://doi.org/10.1016/j.jcyt.2014.09.010 PMid:25593078

48. Fu X, Hua R, Wang X, et al. Synergistic Improvement in Children with Cerebral Palsy Who Underwent Double-Course Human Wharton’s Jelly Stem Cell Transplantation. Stem Cells Int. 2019;2019:7481069. Published 2019 Sep 17. doi:10.1155/2019/7481069. https://doi.org/10.1155/2019/7481069 PMid:31636676 PMCid:PMC6766101

49. Sun JM, Song AW, Case LE, et al. Effect of Autologous Cord Blood Infusion on Motor Function and Brain Connectivity in Young Children with Cerebral Palsy: A Randomized, Placebo-Controlled Trial. Stem Cells Transl Med. 2017;6(12):2071-2078. doi:10.1002/sctm.17-0102/

50. Chen G, Wang Y, Xu Z, et al. Neural stem cell-like cells derived from autologous bone mesenchymal stem cells for the treatment of patients with cerebral palsy. J Transl Med. 2013;11:21. Published 2013 Jan 26. doi:10.1186/1479-5876-11-21/ https://doi.org/10.1186/1479-5876-11-21 PMid:23351389 PMCid:PMC3563497

51. Min K, Song J, Kang JY, et al. Umbilical cord blood therapy potentiated with erythropoietin for children with cerebral palsy: a double-blind, randomized, placebo-controlled trial. Stem Cells. 2013;31(3):581-591. doi:10.1002/stem.1304/ https://doi.org/10.1002/stem.1304 PMid:23281216 PMCid:PMC3744768

52. Miao X, Wu X, Shi W. Umbilical cord mesenchymal stem cells in neurological disorders: A clinical study. Indian J Biochem Biophys. 2015;52(2):140-146.

53. Novak I, Walker K, Hunt RW, Wallace EM, Fahey M, Badawi N. Concise Review: Stem Cell Interventions for People With Cerebral Palsy: Systematic Review With Meta-Analysis. Stem Cells Transl Med. 2016;5(8):1014-1025. doi:10.5966/sctm.2015-0372. https://doi.org/10.5966/sctm.2015-0372 PMid:27245364 PMCid:PMC4954458

54. Eggenberger S, Boucard C, Schoeberlein A, et al. Stem cell treatment and cerebral palsy: Systemic review and meta-analysis. World J Stem Cells. 2019;11(10):891-903. doi:10.4252/wjsc.v11.i10.891. https://doi.org/10.4252/wjsc.v11.i10.891 PMid:31692977 PMCid:PMC6828595

How to cite

Petriv T, Tatarchuk M, Tsymbaliuk Ya, Tsymbaliuk Yu, Tsymbaliuk V. Stem cells transplantation in the treatment of patients with cerebral palsy. Cell Organ Transpl. 2020; 8(1):76-80. doi:10.22494/cot.v8i1.107

Is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.