Functional properties and features of clinical application of adipose-derived stem cells in aesthetic medicine and dermatology: a brief review

Home/2019, Vol. 7, No. 2/Functional properties and features of clinical application of adipose-derived stem cells in aesthetic medicine and dermatology: a brief review

Cell and Organ Transplantology. 2019; 7(2):174-178.
DOI: 10.22494/cot.v7i2.103

Functional properties and features of clinical application of adipose-derived stem cells in aesthetic medicine and dermatology: a brief review

Ivanishchev V.
Chebotarev State Institute of Gerontology of the National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine

Abstract
Clinical and experimental data on the application of adipose stem cells in aesthetic medicine and dermatology were analyzed in this brief review. Adipose tissue is a source of safe and easily accessible autologous stem cells with high regenerative potential. The results of numerous experimental and clinical studies prove the prospect of using adipose derived stem cells for the treatment of various skin diseases, as well as in the complex therapy of chrono- and photoaging of the skin.

Key words: adipose-derived stem cells; skin disorders; skin aging; aesthetic medicine

Full Text PDF (eng) Full Text PDF (ua)

1. Araviyskaya ЕR. Vozrastnye izmeneniya v derme: novye svedeniya i puti korrektsii s pomoshch’yu sredstv dlya ezhednevnogo ukhoda [Age-related changes in the dermis: new information and ways of correction with the help of daily care products]. Russkiy meditsinskiy zhurnal – Russian medical journal. 2008; 8:574-575. [In Russian]
2. Araviyskaya ЕR, Sokolovsky EV. Rukovodstvo po dermatokosmetologii [Guide to dermatocosmetology]. SPb: Foliant, 2008. 632 p. [In Russian]
3. Vermel AE. Stvolovye kletki: obshchaya kharakteristika i perspektivy primeneniya v klinicheskoy praktike [Stem cells: general characteristics and prospects for use in clinical practice]. Klin med. 2004; 1:5-10. [In Russian]
4. Vorobiev AA, Chigrova NA, Pylaeva IO, Barinova EA. Kosmetologicheskaya anatomiya litsa [Cosmetological anatomy of the face]. SPb: Elbi, 2017. 280 p. [In Russian]
5. Gulikyan GN, Karapetyan GE, Pakhomova RA, Kochetova LV. Effektivnost’ autotransplantatsii zhirovoy tkani po dannym literatury [The effectiveness of autologous transplantation of adipose tissue according to the literature]. Sovremennye problemy nauki i obrazovaniya. 2015; 6. http://www.science-education.ru/ru/article/view?id=23699. [In Russian]
6. Zorina A. Dermal’nye fibroblasty: raznoobrazie fenotipov fiziologicheskikh funktsiy, rol’ v starenii kozhi [Dermal fibroblasts: a variety of phenotypes of physiological functions, a role in skin aging]. Esteticheskaya meditsina. 2012; 11(1):15-31. [In Russian]
7. Kalyuzhnaya LD. Starenie kozhi i khronicheskie dermatozy u zhenshchin menopauzal’nogo perioda [Skin aging and chronic dermatoses in menopausal women]. 2006. https://mazg.com.ua/ru-issue-article-10. [In Russian]
8. Kirsanova LV. Izmeneniya kozhi shei u zhenshchin i ikh korrektsiya s primeneniem fraktsionnogo fototermoliza i infrakrasnogo termoliftinga [Changes in the skin of the neck in women and their correction using fractional photothermolysis and infrared thermal lifting]. Dissertatsiya na soiskanie stepeni kandidata mednauk. SPb, 2015. 184 р. [In Russian]
9. Kosmacheva SM, Wolf MV, Potapnev MP. Stvolovye kletki vzroslykh: problemy polucheniya, differentsirovki in vitro, perspektivy klinicheskogo primeneniya [Adult stem cells: problems of obtaining, in vitro differentiation, prospects for clinical use]. Meditsinskie novosti. 2008; 9. http://www.mednovosti.by/journal.aspx?article=3991. [In Russian]
10. Payushina OV. Lokalizatsiya i funktsii mezenkhimnykh stromal’nykh kletok in vivo [Localization and function of mesenchymal stromal cells in vivo]. Zhurnal obshchey biologii – Biology Bulletin Review. 2015; 2:161-172. [In Russian]
11. Petrenko AYu, Ivanov EN, Petrenko YuA. Stvolovye kletki iz zhirovoy tkani [Adipose Stem Cells]. Biotekhnologiya – Biotechnology. 2008; 1(4):39-48. [In Russian]
12. Startseva OI, Melnikov DV, Zakharenko AS, Kirillova KA, Ivanov SI, Pishchikova ED, et al. Mezenkhimal’nye stvolovye kletki zhirovoy tkani: sovremennyy vzgdyad, aktual’nost’ i perspektivy primeneniya v plasticheskoy khirurgii [Adipose tissue mesenchymal stem cells: a modern view, relevance and prospects of use in plastic surgery]. Issledovaniya i praktika v meditsine – Research and practical medicine journal. 2016; 3(3):68-75. [In Russian] https://doi.org/10.17709/2409-2231-2016-3-3-7
13. Takha TV, Nazhmutdinova DK. Kletochnye tekhnologii v kosmetologii i dermatologii [Cell technology in cosmetology and dermatology]. RMZh – RMJ. 2013; 22:1092. https://www.rmj.ru/articles/dermatologiya/Kletochnye_tehnologii_v_kosmetologii_i_dermatologii/#ixzz5xcuevHR9. [In Russian]
14. Terskikh VV, Kiseleva EV. Biologicheskie osobennosti i terapevticheskiy potentsial stromal’nykh kletok zhirovoy tkani. Obzor [Biological peculiarities and therapeutic potential of stromal cells of adipose tissue. Review]. Биологические особенности и терапевтический потенциал стромальных клеток жировой ткани. Обзор. Plasticheskaya khirurgiya i kosmetologiya – Plastic Surgery and Cosmetology 2010; 4(6):13-21. [In Russian]
15. Chertkov IL. Differentsirovochnyy potentsial stvolovykh kletok [Stem Cell Differentiation Potential]. Vestnik RAMN – Annals RAMS. 2005; 10:37-44. [In Russian]
16. Hernandez EI, Margolin AA, Petrukhina A. Lipidnyy bar’er kozhi i kosmeticheskie sredstva [Skin lipid barrier and cosmetics]. М.: Kosmetika i meditsina, 2005. 400 p. [In Russian]
17. Owczarczyk-Saczonek A., Wociór A., Placek W., Maksymowicz W., Wojtkiewicz J. The Use of Adipose-Derived Stem Cells in Selected Skin Diseases (Vitiligo, Alopecia, and Nonhealing Wounds). Stem Cells Int. 2017. URL: https://doi.org/10.1155/2017/4740709.
https://doi.org/10.1155/2017/4740709
PMid:28904532 PMCid:PMC5585652
18. Brown SA, Levi B, Lequex C, Wong VW, Mojallal A, Longaker MT. Basic science review on adipose tissue for clinicians. Plast Reconstr Surg. 2010; 126(6):1409-22.
https://doi.org/10.1097/PRS.0b013e3181f44790
PMid:21124133
19. Caplan AI. Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. J Cell Physiol. 2007; 213(2):341-347.
https://doi.org/10.1002/jcp.21200
PMid:17620285
20. Charles-de-Sá L, Gontijo-de-Amorim NF, Maeda Takiya C, Borojevic R, Benati D, Bernardi P, et al. Antiaging treatment of the facial skin by fat graft and adipose-derived stem cells. Plast Reconstr Surg. 2015; 135(4):999-1009.
https://doi.org/10.1097/PRS.0000000000001123
PMid:25811565
21. Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D, et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International society for cellular therapy position statement. Cytotherapy. 2006; 8(4):315-7.
https://doi.org/10.1080/14653240600855905
PMid:16923606
22. Farage АM, Miller WK, Maibach IH. Textbook of Aging Skin. Springer, 2017. 2222 p.
https://doi.org/10.1007/978-3-662-47398-6
23. Fenske NA, Lober CW. Structural and functional changes of normal aging skin. JAAD. 1986; 15(4):571-585.
https://doi.org/10.1016/S0190-9622(86)70208-9
24. Jackson WM, Nesti LJ, Tuan RS. Mesenchymal stem cell therapy for attenuation of scar formation during wound healing. Stem Cell Res Ther. 2012; 3(3):20. DOI: 10.1186/scrt111.
https://doi.org/10.1186/scrt111
PMid:22668751 PMCid:PMC3392767
25. Kaviani R, Jalili R. Application of Adipose Derived Stem Cells for Treatment of Chronic Wounds. Invest Dermatol Venereol Res. 2016; 2(1):44-51.
26. Fukuoka H, Suga H. Hair regeneration treatment using adipose-derived stem cell conditioned medium: follow-up with trichograms. Eplasty. 2015; 26(15):10.
27. Hyeonwoo Kim, Mi Ri Hyun, Sang Wha Kim. The Effect of Adipose-Derived Stem Cells on Wound Healing: Comparison of Methods of Application. Stem Cells Int. 2019. https://doi.org/10.1155/2019/2745640.
https://doi.org/10.1155/2019/2745640
PMid:31636674 PMCid:PMC6766154
28. Kelly RI, Pearse R, Bull R, Leveque JL, de Rigal J, Mortimer P. The effects of aging on cutaneous microvasculature. J Am Acad Dermatol. 1995; 33(5):749-756.
https://doi.org/10.1016/0190-9622(95)91812-4
29. Kim WS, Park BS, Sung JH, Yang JM, Park SB, Kwak SJ, et al. Wound healing effect of adipose-derived stem cells: a critical role of secretory factors on human dermal fibroblasts. J Dermatol Sci. 2007; 48:15-24.
https://doi.org/10.1016/j.jdermsci.2007.05.018
PMid:17643966
30. Kim WS, Park BS, Park SH, Kim HK, Sung JH. Antiwrinkle effect of adipose-derived stem cell: activation of dermal fibroblast by secretory factors. J Dermatol Sci. 2009; 53(2):96-10.
https://doi.org/10.1016/j.jdermsci.2008.08.007
PMid:18829265
31. Lee A, Kim J, Park C, Lee J, Lee C, Do B. Co-culture of Melanocytes with Adipose-derived Stem Cells as a Potential Substitute for Co-culture with Keratinocytes. Acta Derm Venereol. 2012; 92(1):16-2.
https://doi.org/10.2340/00015555-1174
https://doi.org/10.2340/16501977-0475
32. Lindros B, Suuronen R, Miettinen S. The potential of adipose stem cells in regenerative medicine. Stem Cell Rev. 2011; 7(2):269-91.
https://doi.org/10.1007/s12015-010-9193-7
PMid:20853072
33. Amirkhani MA, Shoae-Hassani A, Soleimani M, Hejazi S, Ghalichi L, Nilforoushzadeh MA. Rejuvenation of facial skin and improvement in the dermal architecture by transplantation of autologous stromal vascular fraction: a clinical study. Bioimpacts. 2016; 6(3):149-154.
https://doi.org/10.15171/bi.2016.21
PMid:27853678 PMCid:PMC5108987
34. Moon KM, Park YH, Lee JS, Chae YB, Kim MM, Kim DS, et al. The effect of secretory factors of adipose-derived stem cells on human keratinocytes. Int J Mol Sci. 2012; 13:1239-57.
https://doi.org/10.3390/ijms13011239
PMid:22312315 PMCid:PMC3269749
35. Murray IR, West CC, Hardy WR, James AW, Park TS, Nguyen A, et al. Natural history of mesenchymal stem cells, from vessel walls to culture vessels. Cell Mol Life Sci. 2014; 71(8):1353-1374.
https://doi.org/10.1007/s00018-013-1462-6
PMid:24158496
36. Neuber G. Uber die Wienderanheilung vollstandig vom Korper getrennter, die ganze Fettschicht enthaltender Hautstucke. Zbl f Chir. 1893; 30:16.
37. Nishioka E, Funasaka Y, Kondoh H, Chakraborty AK, Mishima Y, Ichihashi M. Expression of tyrosinase, TRP-1 andTRP-2 in ultraviolet-irradiated human melanomas and melanocytes: TRP-2 protects melanoma cells from ultraviolet B- induced apoptosis. Melanoma Res. 1999; 9:433-443.
https://doi.org/10.1097/00008390-199910000-00002
PMid:10596909
38. Naderi N, Combellack E, Griffin M, et al. The regenerative role of adipose-derived stem cells (ADSCs) in plastic and reconstructive surgery. Int Wound J. 2017; 14:112-124.
https://doi.org/10.1111/iwj.12569
PMid:26833722
39. Oedayrajsingh-Varma MJ, van Ham SM, Knippenberg M, Helder MN, Klein-Nulend J, Schouten TE, et al. Adipose tissue-derived mesenchymal stem cell yield and growth characteristics are affected by the tissue-harvesting procedure. Cytotherapy. 2006; 8(2):166-77.
https://doi.org/10.1080/14653240600621125
PMid:16698690
40. Park BS, Jang AK, Sung HJ, Park SJ, Kwon HY. Adipose-Derived Stem Cells and Their Secretory Factors as a Promising Therapy for Skin Aging. Dermatol Surg. 2008; 34:1323-1326.
https://doi.org/10.1111/j.1524-4725.2008.34283.x
https://doi.org/10.1097/00042728-200810000-00003
PMid:18616537
41. Park BS, Jang AK, Sung HJ, Park SJ, Kwon HY. Adipose-Derived Stem Cells and Their Secretory Factors as a Promising Therapy for Skin Aging. Dermatol Surg. 2008; 34:1323-1326.
https://doi.org/10.1111/j.1524-4725.2008.34283.x
https://doi.org/10.1097/00042728-200810000-00003
PMid:18616537
42. Park BS, Kim WS, Choi JS, Kim HK, Won JH, Ohkubo F, et al. Hair growth stimulated by conditioned medium of adipose-derived stem cells is enhanced by hypoxia: evidence of increased growth factor secretion. Biomed Res. 2010; 31(1):27-34.
https://doi.org/10.2220/biomedres.31.27
PMid:20203417
43. Perez-Meza D, Ziering C, Sforza M, Krishnan G, Ball E, Daniels E. Hair follicle growth by stromal vascular fraction-enhanced adipose transplantation in baldness. Stem Cells Cloning. 2017; 10:1-10. DOI: 10.2147/SCCAA.S131431.
https://doi.org/10.2147/SCCAA.S131431
PMid:28740409 PMCid:PMC5506773
44. Rehman J, Traktuev D, Li J, Merfeld-Clauss S, Temm-Grove SG, Bovenkerk SJ, et al. Secretion angiogenic and antiopoptotic factors by human adipose stromal cell. Circulaton. 2004; 109:1292-1298.
https://doi.org/10.1161/01.CIR.0000121425.42966.F1
PMid:14993122
45. Rittie Laure, Fisher Gary J. Natural and Sun-Induced Aging of Human Skin. Cold Spring Harb Perspect Med. 2015. DOI: 10.1101/cshperspect.a015370.
https://doi.org/10.1101/cshperspect.a015370
PMid:25561721 PMCid:PMC4292080
46. Rodbell M. Metabolism of isolated fat cells. Effects of hormones on glucose metabolism and lipolysis. Dis Metab.1964; 239(2):375-380.
47. Rodbell M, Jones AB. Metabolism of isolated fat cells. The similar inhibitory action of phospholipase c (Clostridium perfringens alpha toxin) and of insulin on lipolysis stimulated by lipolytic hormones and theophylline. J Biol Chem. 1966; 241(1):140-142.
48. Tobin DJ. Introduction to SKIN aging. J Tissue Viability. 2017; 26(1):37- 4.
https://doi.org/10.1016/j.jtv.2016.03.002
PMid:27020864
49. Wang Jing, Liao Yunjun, Xia Jing, Wang Zijue, Mo Xiaopei, Feng Jingwei, et al. Mechanical micronization of lipoaspirates for the treatment of hypertrophic scars. Stem Cell Res Ther. 2019. https://stemcellres.biomedcentral.com/articles/10.1186/s13287-019-1140-1.
https://doi.org/10.1186/s13287-019-1140-1
PMid:30678729 PMCid:PMC6345005
50. Waller JM, Maibach HI. Age and skin structure and function, a quantitative approach (I): blood flow, pH, thickness, and ultrasound echogenicity. Skin Res Technol. 2005; 11(4):221-35.
https://doi.org/10.1111/j.0909-725X.2005.00151.x
PMid:16221138
51. Zarei F, Abbaszadeh A. Application of Cell Therapy for Anti-Aging Facial Skin. Curr Stem Cell Res Ther. 2019; 14(3):244-248.
https://doi.org/10.2174/1574888X13666181113113415
PMid:30421684
52. Zografou A, Papadopoulos O, Tsigris C, et al. Autologous transplantation of adipose-derived stem cells enhances skin graft survival and wound healing in diabetic rats. Ann Plast Surg. 2013; 71(2):225-232.
https://doi.org/10.1097/SAP.0b013e31826af01a
PMid:23636118
53. Zuk PA, Zhu M, Ashjian P. Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell. 2002; 13(12):4279-95.
https://doi.org/10.1091/mbc.e02-02-0105
PMid:12475952 PMCid:PMC138633

Ivanishchev V. Functional properties and features of clinical application of adipose-derived stem cells in aesthetic medicine and dermatology: a brief review. Cell and Organ Transplantology. 2019; 7(2):174-178. doi:10.22494/cot.v7i2.103

Creative Commons License
Is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.