Cell and Organ Transplantology. 2017; 5(2):159-163.
DOI: 10.22494/COT.V5I2.74
The role of HLA-typing in transplantation of hematopoietic stem cells
Khomenko V. I.
Kyiv Center of Bone Marrow Transplantation, Kyiv, Ukraine
Abstract
The system of human leukocyte antigen (HLA) and HLA-typing were used to match a potential donor with a recipient for allogeneic hematopoietic stem cell transplantation (HSCT). The HLA matching between donor and recipient is key role in allogeneic HSCT. The mismatch of HLA can cause graft rejection, graft-versus-host disease and decrease survival in patients receiving grafts from both related and unrelated donors. The adverse HLA effect on the outcome depends on the total number of mismatched alleles/loci and the resolution level of the mismatch (antigen or allele level).
Thus, the final choice of compatible donor-recipient pairs should be based on high resolution molecular-genetic methods of HLA-typing. Serologic and molecular genetic methods of low resolution HLA-typing, which are cheaper than HLA-typing high-resolution, should be used for donor screening studies. HSCT from a fully compatible donor, matched high-resolution HLA-typing methods gives better results than from partially compatible. In some clinical circumstances, a partially compatible donor may be as effective as fully compatible. The selection of such a donor, taking into account the controversy of data from various literary sources, should be based on own research and experience. Creation and development of a Ukrainian database of donors with the HLA-haplotype specific to the indigenous population will make search of matching pairs of donor recipients more effective and cost-effective.
Key words: allogeneic hematopoietic stem cell transplantation (HSCT); human leucocyte antigens; HLA-typing
Full Text PDF (eng) Full Text PDF (ua)1. Nowak J. Role of HLA in hematopoietic SCT. Bone Marrow Transplantation. 2008; 42: 71-76. https://doi.org/10.1038/bmt.2008.288 PMid:18978750 |
||||
2. Morichima Y, Kashiwase K, Matsuo K, et al. Biological significance of HLA locus matching in unrelated donor bone marrow transplantation. Blood. 2015; 125(7): 1189-1197. https://doi.org/10.1182/blood-2014-10-604785 PMid:25519752 PMCid:PMC4326776 |
||||
3. Kekre N, Antin J. Hematopoietic stem cell transplantation donor sources in the 21st century: Сhoosing the ideal donor when a perfect match doesn’t exist. Blood. 2014; 124(3): 334-343. https://doi.org/10.1182/blood-2014-02-514760 PMid:24914138 |
||||
4. Park M, Seo JJ. Role of HLA in Hematopoietic Stem Cell Transplantation. Bone Marrow Research. 2012; doi: 10.1155/2012/680841. https://doi.org/10.1155/2012/680841 |
||||
5. Kuzmich EV, Alyansky AL, Ivanova NE. Analiz rezul’tatov allogennoy transplantatsii gemopoeticheskikh stvolovykh kletok v zavisimosti ot stepeni HLA-podbora patsienta i nerodstvennogo donora [Analysis of the results of allogeneic transplantation of hematopoietic stem cells depending on the degree of HLA selection of the patient and unrelated donor]. Onkogematologiya – Oncohematology. 2014; 9(3): 25-31. [In Russian] | ||||
6. Bubnova LN, Pavlova IE, Glazanova TV, et al. Registry donorov gemopoeticheskikh stvolovykh kletok [Donor Register of hematopoietic stem cell]. Biomeditsinskiy zhurnal Medline.ru – Biomedical Journal Medline.ru. 2015; 16: 751-758. | ||||
7. Makarenko OA, Alyanskiy AL, Ivaniva NE. Effektivnost’ poiska nerodstvennogo donora gemopoeticheskikh stvolovykh kletok c pomoshch’yu rossiyskoy poiskovoy sistemy Bone Marrow Donor Search: opyt NII detskoy onkologii, gematologii i transplantologii im. R. M. Gorbachevoy [Effectiveness of Search for an Unrelated Donor of Hematopoietic Stem Cells using Russian Date Base «Bone Marrow Donor Search»: Experience of Raisa Gorbacheva Memorial Institute for Children Oncology, Hematology and Transplantation]. Klinicheskaya onkogematologiya – Clinical oncohematology. 2017; 10(1): 39-44. [In Russian] | ||||
8. Afanasiev BV, Zubarovskaya LS, Moiseev IS. Allogennaya transplantatsiya gemopoeticheskikh stvolovykh kletok u detey: nastoyashchee, problemy, perspektivy [Afanasiev BV, Zubarovskaya LS, Moiseev IS. Allogeneic hematopoietic stem cell transplantation in children: now, problems and prospects]. Rossiyskiy zhurnal detskoy gematologii i onkologii – Russian Journal of Children Hematology and Oncology. 2015; 2(2): 28-42. [In Russian] | ||||
9. Passweg JR, Baldomero H, Bader P, et al. Use of haploidentical stem cell transplantation continues to increase: the 2015 European Society for Blood and Marrow Transplant activity survey report. Bone Marrow Transplantation. 2017; 52: 811-817. https://doi.org/10.1038/bmt.2017.34 PMid:28287639 PMCid:PMC5467246 |
||||
10. Passweg JR, Baldomero H, Bader P, et al. Hematopoietic stem cell transplantation in Europe 2014: more than 40 000 transplants annually. Bone Marrow Transplantation. 2016; 51: 786-792. https://doi.org/10.1038/bmt.2016.20 PMid:26901709 PMCid:PMC4895175 |
||||
11. Loginova MA, Paramonov IV, Trofimova NP. Neodnoznachnosti pri provedenii HLA-tipirovaniya po tekhnologi SSO i popytka ikh razresheniya [Ambiguity in HLA-typing with SSO technology and attempting to resolve them]. Vestnik transplantologii i iskusstvennykh organov – Russian Journal of Transplantology and Artificial Organs. 2010; 12(4): 33-38. [In Russian] | ||||
12. Shaw BE, Arguello R, Garcia-Sepulveda CA, et al. The impact of HLA genotyping on survival following unrelated donor haematopoietic stem cell transplantation. British Journal of Haematology. 2010; 150: 251-258. https://doi.org/10.1111/j.1365-2141.2010.08224.x PMid:20560963 |
||||
13. Balint B, Pavlovic M, Todorovic M. Recent strategies vs. challenges in stem cell-based grafting: from innovative research to clinical practice. Bilt Transfuziol. 2011; 57(1-2): 9-25. | ||||
14. Bone Marrow Donor Worldwide, Stem Cell Donor Registries Statistics. Available: http://www.bmdw.org/26-bmdw/news-and-publications/statistics/84-stem-cell-donor-registries. | ||||
15. Tiercy JM. Unrelated Hematopoietic Stem Cell Donor Matching Probability and Search Algorithm. Bone Marrow Research. 2012; 2012. 8 p. | ||||
16. Elmaagacli AH. Unrelated transplantation: donors issues. Ulusal Kemik İliği Transplantasyonu ve Kök Hücre Tedavileri Kongresi. 08 – 10 Mart 2012, Antalya. Available: http://www.thd.org.tr/thdData/Books/232/unrelated-transplantation-donor-issues-ahmet-h-elmaagacli.pdf | ||||
17. Bergstrom T, Garratt R, Sheehan-Connor D. One Chance in a Million: Altruism and the Bone Marrow Registry. Departmental Working Papers, Department of Economics, UCSB, University of California, Santa Barbara, 2008. 41 p. | ||||
18. Lee SJ, Klein J, Haagenson M, et al. High-resolution donor-recipient HLA matching contributes to the success of unrelated donor marrow transplantation. Blood. 2007; 110: 4576-4583. https://doi.org/10.1182/blood-2007-06-097386 PMid:17785583 |
||||
19. Gratwohl A. The EBMT risk score. Bone Marrow Transplantation. 2012; 47: 749-56. https://doi.org/10.1038/bmt.2011.110 PMid:21643021 |
||||
20. Crocchiolo R, Ciceri F, Fleischhauer K, et al. HLA matching affects clinical outcome of adult patients undergoing haematopoietic SCT from unrelated donors: a study from the Gruppo Italiano Trapianto di Midollo Osseo and Italian Bone Marrow Donor Registry. Bone Marrow Transplantation. 2009; 44: 571-577. https://doi.org/10.1038/bmt.2009.67 PMid:19363528 |
||||
21. Morishima Y, Sasazuki T, Inoko H, et al. The clinical significance of human leukocyte antigen (HLA) allele compatibility in patients receiving a marrow transplant from serologically HLA-A, HLA-B, and HLA-DR matched unrelated donors. Blood. 2002; 99: 4200-4206. https://doi.org/10.1182/blood.V99.11.4200 PMid:12010826 |
||||
22. Flomenberg N, Baxter-Lowe LA, Confer D, et al. Impact of HLA class I and class II high-resolution matching on outcomes of unrelated donor bone marrow transplantation: HLA-C mismatching is associated with a strong adverse effect on transplantation outcome. Blood. 2004; 104: 1923-1930. https://doi.org/10.1182/blood-2004-03-0803 PMid:15191952 |
Khomenko VI. The role of HLA-typing in transplantation of hematopoietic stem cells. Cell and Organ Transplantology. 2017; 5(2):159-163. doi:10.22494/cot.v5i2.74
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