Cell and Organ Transplantology. 2023; 11(2):82-86.
DOI: 10.22494/cot.v11i2.153
The efficacy of two models – MEAF and pMELD, as indicators of lethal outcome in early postoperative period after liver transplantation in children
Goncharov A.
, Uzunova Y.
- University Hospital “Lozenetz”, Sofia University “St. Kliment Ohridski”, Sofia, Bulgaria
Abstract
Early allograft dysfunction following liver transplantation is a clinical entity that represents a condition in which the liver graft shows some degree of hepatic injury, but the functions are sufficient to support life. Many models have been developed to individualize the risk of transplant failure that include parameters that are significantly associated with allograft dysfunction.
Purpose. The current study is aiming to prove the effectiveness and compare “Model for Early Allograft Function” (MEAF) and “postoperative Model for End-stage Liver Disease” (pMELD) in the early post-transplant setting in children.
Methods. We carried out a retrospective study on 43 liver transplant patients for a 17-year period between the ages 0-18 years. MEAF and pMELD were calculated on the third and fifth postoperative day, respectively, and a Cox regression analysis was performed to find the correlation between them and mortality in the early postoperative period.
Results. Both scores proved to be statistically significant and applicable in early postoperative period. MEAF had p value of 0.0003 and a hazard ratio of 10.99, while pMELD demonstrated p value of 0.003 and a hazard ratio of 1.24.
Conclusion. Both MEAF and pMELD can be used for the diagnostics of early allograft dysfunction and predicting the outcome of the liver transplantation in children, with MEAF having the upper hand.
Key words: pediatric liver transplantation; early allograft dysfunction; graft survival
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Goncharov A, Uzunova Y. The efficacy of two models – MEAF and pMELD, as indicators of lethal outcome in early postoperative period after liver transplantation in children. Cell Organ Transpl. 2023; 11(2):82-86. Available from: https://doi.org/10.22494/cot.v11i2.153
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