Cell and Organ Transplantology. 2013; 1(1): 19-23.
DOI: 10.22494/COT.V1I1.53
Allogenic umbilical cord blood transplantation for a child with chromosomal abnormality: a case report
Jae Sun Shim, Kyounghoon Min, MinYoung Kim
CHA Bundang Medical Center, CHA University, Seongnam-si, Republic of Korea
Abstract
A quite number of patients with global developmental delay (GDD) or mental retardation (MR) have chromosomal abnormalities. Comprehensive rehabilitation therapy helps improve the clinical functions of the patients, but there is no fundamental treatment option for GDD or MR. Umbilical cord blood transplantation (UCBT) showed examples of synthesis essays https://jump4loves.com its safety and efficacy through a lot of animal studies and some clinical trials to date. Erythropoietin (EPO) is an option for adjunctive therapy when combined with cell therapy. We treated a child who had GDD and complex chromosome rearrangement with an allogenic UCBT and concurrent EPO injections, and observed clinical improvements, and confirmed the safety of the procedure.
| 1. Majnemer A, Shevell M. I. Diagnostic yield of the neurologic assessment of the developmentally delayed child. J Pediatr. 1995; 127(2):193-9. https://doi.org/10.1016/S0022-3476(95)70294-6 |
||||
| 2. Moeschler JB, Shevell M. American Academy of Pediatrics Committee on G. Clinical genetic evaluation of the child with mental retardation or developmental delays. Pediatrics. 2006; 117(6):2304-16. https://doi.org/10.1542/peds.2006-1006 PMid:16740881 |
||||
| 3. Tirosh E, Jaffe M. Global developmental delay and mental retardation–a pediatric perspective. Dev Disabil Res Rev. 2011; 17(2):85-92. https://doi.org/10.1002/ddrr.1103 PMid:23362028 |
||||
| 4. Vendrame M, Cassady J, Newcomb J, et al. Infusion of human umbilical cord blood cells in a rat model of stroke dose-dependently rescues behavioral deficits and reduces infarct volume. Stroke. 2004; 35(10):2390-5. https://doi.org/10.1161/01.STR.0000141681.06735.9b PMid:15322304 |
||||
| 5. Nan Z, Grande A, Sanberg CD, et al. Infusion of human umbilical cord blood ameliorates neurologic deficits in rats with hemorrhagic brain injury. Ann NY Acad Sci. 2005; 1049:84-96. https://doi.org/10.1196/annals.1334.009 PMid:15965109 |
||||
| 6. Lu D, Sanberg P. R, Mahmood A, et al. Intravenous administration of human umbilical cord blood reduces neurological deficit in the rat after traumatic brain injury. Cell Transplant. 2002; 11(3):275-81. PMid:12075993 |
||||
| 7. Nikolic W. V, Hou H, Town T, et al. Peripherally administered human umbilical cord blood cells reduce parenchymal and vascular beta-amyloid deposits in Alzheimer mice. Stem Cells Dev. 2008; 17(3):423-39. https://doi.org/10.1089/scd.2008.0018 PMid:18366296 PMCid:PMC2649688 |
||||
| 8. Dusing SC, Thorpe DE, Poe MD, et al. Gross examples of synthesis essays https://jump4loves.com motor development of children with hurler syndrome after umbilical cord blood transplantation. Phys Ther. 2007; 87(11):1433-40. https://doi.org/10.2522/ptj.20070017 PMid:17785373 |
||||
| 9. Escolar ML, Poe MD, Martin HR, et al. A staging system for infantile Krabbe disease to predict outcome after unrelated umbilical cord blood transplantation. Pediatrics. 2006; 118(3):e879-89. https://doi.org/10.1542/peds.2006-0747 PMid:16923928 |
||||
| 10. Asadi B, Askari GR, Khorvash F, et al. Neuroprotective effects of erythropoietin in acute ischemic stroke. Int J Prev Med. 2013; 4(Suppl 2):S306-12. PMid:23776743 PMCid:PMC3678237 |
||||
| 11. Mammis A, McIntosh TK.Maniker A. H. Erythropoietin as a neuroprotective agent in traumatic brain injury. Review Surg Neurol. 2009; 71(5):527-31. https://doi.org/10.1016/j.surneu.2008.02.040 PMid:18789503 |
||||
| 12. Iwai M, Cao G, Yin W, et al. Erythropoietin promotes neuronal replacement through revascularization and neurogenesis after neonatal hypoxia/ischemia in rats. Stroke. 2007; 38(10):2795-803. https://doi.org/10.1161/STROKEAHA.107.483008 PMid:17702962 |
||||
| 13. Koh SH, Noh MY, Cho GW, et al. Erythropoietin increases the motility of human bone marrow-multipotent stromal cells (hBM-MSCs) and enhances the production of neurotrophic factors from hBM-MSCs. Stem Cells Dev. 2009; 18(3):411-21. https://doi.org/10.1089/scd.2008.0040 PMid:18590375 |
||||
| 14. Min K, Song J, Kang JY, et al. Umbilical cord blood therapy potentiated with erythropoietin for children with cerebral palsy: a double-blind, randomized, placebo-controlled trial. Stem Cells. 2013; 31(3):581-91. https://doi.org/10.1002/stem.1304 PMid:23281216 PMCid:PMC3744768 |
||||
| 15. Rubinstein P, Dobrila L, Rosenfield RE, et al. Processing and cryopreservation of placental/umbilical cord blood for unrelated bone marrow reconstitution. Proc Natl Acad Sci USA. 1995; 92(22):10119-22. https://doi.org/10.1073/pnas.92.22.10119 PMid:7479737 PMCid:PMC40747 |
||||
| 16. Min K, Yu S, Lee J, et al. Reliability of Fractional Anisotropy Measurement for Children with Cerebral Palsy. Neuropediatrics. 2013; in publishing. | ||||
| 17. Pai GS, Thomas GH, Mahoney W, et al. Complex chromosome rearrangements. Report of a new case and literature review. Clin Genet. 1980; 18(6):436-44. https://doi.org/10.1111/j.1399-0004.1980.tb01790.x PMid:7449183 |
||||
| 18. Madan K. What is a complex chromosome rearrangement?. Am J Med Genet A. 2013; 161A(5):1181-4. https://doi.org/10.1002/ajmg.a.35834 PMid:23532917 |
||||
| 19. Monfort S, Blesa D, Rosello M, et al. Duplication of 14q11.2 associates with short stature and mild mental retardation: a putative relation with quantitative trait loci. Am J Med Genet A. 2007; 143(4):382-4. https://doi.org/10.1002/ajmg.a.31608 PMid:17230491 |
||||
| 20. Moortgat S, Verellen-Dumoulin C, Maystadt I, et al. Developmental delay and facial dysmorphism in a child with an 8.9 Mb de novo interstitial deletion of 3q25.1-q25.32: Genotype-phenotype correlations of chromosome 3q25 deletion syndrome. Eur J Med Genet. 2011; 54(2):177-80. https://doi.org/10.1016/j.ejmg.2010.11.011 PMid:21167329 |
||||
| 21. Zahir F, Firth HV, Baross A, et al. Novel deletions of 14q11.2 associated with developmental delay, cognitive impairment and similar minor anomalies in three children. J Med Genet. 2007; 44(9):556-61. https://doi.org/10.1136/jmg.2007.050823 PMid:17545556 PMCid:PMC2597953 |
||||
| 22. Madan K. Balanced complex chromosome rearrangements: reproductive aspects. A review Am J Med Genet A. 2012; 158A(4):947-63. https://doi.org/10.1002/ajmg.a.35220 PMid:22383246 |
||||
| 23. Shao B, Cheng Y, Jin K. Estrogen, neuroprotection and neurogenesis after ischemic stroke. Curr. Drug Targets. 2012; 13(2):188-98. https://doi.org/10.2174/138945012799201702 |
||||
| 24. Wang L, Zhang Z, Wang Y, et al. Treatment of stroke with erythropoietin enhances neurogenesis and angiogenesis and improves neurological function in rats. Stroke. 2004; 35(7):1732-7. https://doi.org/10.1161/01.STR.0000132196.49028.a4 PMid:15178821 |
||||
| 25. Mezey E, Chandross K. J, Harta G, et al. Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow. Science. 2000; 290(5497):1779-82. https://doi.org/10.1126/science.290.5497.1779 PMid:11099419 |
||||
| 26. Willing A. E, Lixian J, Milliken M, et al. Intravenous versus intrastriatal cord blood administration in a rodent model of stroke. J Neurosci Res. 2003; 73(3):296-307. https://doi.org/10.1002/jnr.10659 PMid:12868063 |
||||
| 27. Pagani M, Manouilenko I, Stone-Elander S, et al. Brief Report: alterations in cerebral blood flow as assessed by PET/CT in adults with autism spectrum disorder with normal IQ. J Autism Dev Disord. 2012; 42(2):313-8. https://doi.org/10.1007/s10803-011-1240-y PMid:21487836 |
||||
| 28. Rumsey JM, Ernst M. Functional neuroimaging of autistic disorders. Ment Retard Dev Disabil Res Rev. 2000; 6(3):171-9. https://doi.org/10.1002/1098-2779(2000)6:3<171::AID-MRDD4>3.0.CO;2-N |
||||
| 29. Chugani DC. Neuroimaging and neurochemistry of autism. Pediatr Clin North Am. 2012; 59(1):63-73. https://doi.org/10.1016/j.pcl.2011.10.002 PMid:22284793 |
||||
| 30. Sharma A, Gokulchandran N, Sane H, et al. Autologous bone marrow mononuclear cell therapy for autism: an open label proof of concept study. Stem Cells Int. 2013; ID 623875.http://dx.doi.org/10.1155/2013/623875. https://doi.org/10.1155/2013/623875 |
||||
| 31. Scheck S, Boyd R, Rose S. New insights into the pathology of white matter tracts in cerebral palsy from diffusion magnetic resonance imaging: A systematic review. Dev Med Child Neurol. 2012; 54:684–96. https://doi.org/10.1111/j.1469-8749.2012.04332.x PMid:22646844 |
||||
| 32. Lichtenwalner RJ, Parent JM. Adult neurogenesis and the ischemic forebrain. J Cereb Blood Flow Metab. 2006; 26(1):1-20. https://doi.org/10.1038/sj.jcbfm.9600170 PMid:15959458 |
||||
Jae Sun Shim, Kyounghoon Min, MinYoung Kim. Allogenic umbilical cord blood transplantation for a child with chromosomal abnormality: a case report. Cell and Organ Transplantology. 2013; 1(1):19-23. doi: 10.22494/COT.V1I1.53
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