Scientific-organizational aspects for developing an inventory of the donors of umbilical cord blood with CCR5 delta32/delta32 genotype for HIV infection treatment

Home/2014, Vol. 2, No. 1/Scientific-organizational aspects for developing an inventory of the donors of umbilical cord blood with CCR5 delta32/delta32 genotype for HIV infection treatment

Cell and Organ Transplantology. 2014; 2(1):39-43.
DOI: 10.22494/COT.V2I1.37

Scientific-organizational aspects for developing an inventory of the donors of umbilical cord blood with CCR5 delta32/delta32 genotype for HIV infection treatment

Pirozhkov I. A.1, 2, Smolyaninov A. B.1, 2, Chechetkin A. V.3, Ivolgin D. A.1,2
1Pokrovsky stem cell bank, St. Petersburg, Russian Federation
2Research laboratory of cell technologies of the Northwest State Medical University I.I. Mechnikov, St. Petersburg, Russian Federation
3Russian Federal State Research Institute of Hematology and Transfusiology of Federal Medical-Biological Agency, St. Petersburg, Russian Federation

Abstract
Projections of the using umbilical cord blood for HIV infection cure consist in the transplantation of umbilical cord blood hematopoietic stem cells from the donors of homozygous CCR5 delta32 mutation carriers.
This work presents the results of screening evaluation of umbilical cord blood samples from the donors, included in the public registry of the Pokrovsky stem cells bank, for identification of the homozygous CCR5 delta32 polymorphism carriers and their following HLA typing to see the perspectives for creating a public registry of CCR5 delta32/ CCR5 delta32 donors of the umbilical cord blood for treatment of HIV-infected patients. Total 2860 umbilical cord blood samples were examined from which 29 samples with CCR5 delta32 / CCR5 delta32 genotype were selected.
High frequency of the HLA alleles most prevalent in the North-West region of the Russian Federation has been found in the donors of umbilical cord blood with wild CCR5 gene and among CCR5 delta32/delta32 donors.

Keywords: umbilical cord blood, HIV, CCR5 delta32, hematopoietic stem cells transplantation

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Pirozhkov IA, Smolyaninov AB, Chechetkin AV, Ivolgin DA. Scientific-organizational aspects for developing an inventory of the donors of umbilical cord blood with ccr5 delta32/delta32 genotype for hiv infection treatment. Cell and Organ Transplantology. 2014; 2(1): doi: 10.22494/COT.V2I1.37

 

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