Allogenic umbilical cord blood transplantation for a child with chromosomal abnormality: a case report

Home/2013, Vol. 1, No. 1/Allogenic umbilical cord blood transplantation for a child with chromosomal abnormality: a case report

Cell and Organ Transplantology. 2013; 1(1): 19-23.
DOI: 10.22494/COT.V1I1.44

Allogenic umbilical cord blood transplantation for a child with chromosomal abnormality: a case report

Jae Sun Shim, Kyounghoon Min, MinYoung Kim
CHA Bundang Medical Center, CHA University, Seongnam-si, Republic of Korea

A quite number of patients with global developmental delay (GDD) or mental retardation (MR) have chromosomal abnormalities. Comprehensive rehabilitation therapy helps improve the clinical functions of the patients, but there is no fundamental treatment option for GDD or MR. Umbilical cord blood transplantation (UCBT) showed its safety and efficacy through a lot of animal studies and some clinical trials to date. Erythropoietin (EPO) is an option for adjunctive therapy when combined with cell therapy. We treated a child who had GDD and complex chromosome rearrangement with an allogenic UCBT and concurrent EPO injections, and observed clinical improvements, and confirmed the safety of the procedure.

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1. Majnemer A, Shevell M. I. Diagnostic yield of the neurologic assessment of the developmentally delayed child. J Pediatr. 1995; 127(2):193-9.
2. Moeschler JB, Shevell M. American Academy of Pediatrics Committee on G. Clinical genetic evaluation of the child with mental retardation or developmental delays. Pediatrics. 2006; 117(6):2304-16.
3. Tirosh E, Jaffe M. Global developmental delay and mental retardation–a pediatric perspective. Dev Disabil Res Rev. 2011; 17(2):85-92.
4. Vendrame M, Cassady J, Newcomb J, et al. Infusion of human umbilical cord blood cells in a rat model of stroke dose-dependently rescues behavioral deficits and reduces infarct volume. Stroke. 2004; 35(10):2390-5.
5. Nan Z, Grande A, Sanberg CD, et al. Infusion of human umbilical cord blood ameliorates neurologic deficits in rats with hemorrhagic brain injury. Ann NY Acad Sci. 2005; 1049:84-96.
6. Lu D, Sanberg P. R, Mahmood A, et al. Intravenous administration of human umbilical cord blood reduces neurological deficit in the rat after traumatic brain injury. Cell Transplant. 2002; 11(3):275-81.
7. Nikolic W. V, Hou H, Town T, et al. Peripherally administered human umbilical cord blood cells reduce parenchymal and vascular beta-amyloid deposits in Alzheimer mice. Stem Cells Dev. 2008; 17(3):423-39.
PMid:18366296 PMCid:PMC2649688
8. Dusing SC, Thorpe DE, Poe MD, et al. Gross motor development of children with hurler syndrome after umbilical cord blood transplantation. Phys Ther. 2007; 87(11):1433-40.
9. Escolar ML, Poe MD, Martin HR, et al. A staging system for infantile Krabbe disease to predict outcome after unrelated umbilical cord blood transplantation. Pediatrics. 2006; 118(3):e879-89.
10. Asadi B, Askari GR, Khorvash F, et al. Neuroprotective effects of erythropoietin in acute ischemic stroke. Int J Prev Med. 2013; 4(Suppl 2):S306-12.
PMid:23776743 PMCid:PMC3678237
11. Mammis A, McIntosh TK.Maniker A. H. Erythropoietin as a neuroprotective agent in traumatic brain injury. Review Surg Neurol. 2009; 71(5):527-31.
12. Iwai M, Cao G, Yin W, et al. Erythropoietin promotes neuronal replacement through revascularization and neurogenesis after neonatal hypoxia/ischemia in rats. Stroke. 2007; 38(10):2795-803.
13. Koh SH, Noh MY, Cho GW, et al. Erythropoietin increases the motility of human bone marrow-multipotent stromal cells (hBM-MSCs) and enhances the production of neurotrophic factors from hBM-MSCs. Stem Cells Dev. 2009; 18(3):411-21.
14. Min K, Song J, Kang JY, et al. Umbilical cord blood therapy potentiated with erythropoietin for children with cerebral palsy: a double-blind, randomized, placebo-controlled trial. Stem Cells. 2013; 31(3):581-91.
PMid:23281216 PMCid:PMC3744768
15. Rubinstein P, Dobrila L, Rosenfield RE, et al. Processing and cryopreservation of placental/umbilical cord blood for unrelated bone marrow reconstitution. Proc Natl Acad Sci USA. 1995; 92(22):10119-22.
PMid:7479737 PMCid:PMC40747
16. Min K, Yu S, Lee J, et al. Reliability of Fractional Anisotropy Measurement for Children with Cerebral Palsy. Neuropediatrics. 2013; in publishing.
17. Pai GS, Thomas GH, Mahoney W, et al. Complex chromosome rearrangements. Report of a new case and literature review. Clin Genet. 1980; 18(6):436-44.
18. Madan K. What is a complex chromosome rearrangement?. Am J Med Genet A. 2013; 161A(5):1181-4.
19. Monfort S, Blesa D, Rosello M, et al. Duplication of 14q11.2 associates with short stature and mild mental retardation: a putative relation with quantitative trait loci. Am J Med Genet A. 2007; 143(4):382-4.
20. Moortgat S, Verellen-Dumoulin C, Maystadt I, et al. Developmental delay and facial dysmorphism in a child with an 8.9 Mb de novo interstitial deletion of 3q25.1-q25.32: Genotype-phenotype correlations of chromosome 3q25 deletion syndrome. Eur J Med Genet. 2011; 54(2):177-80.
21. Zahir F, Firth HV, Baross A, et al. Novel deletions of 14q11.2 associated with developmental delay, cognitive impairment and similar minor anomalies in three children. J Med Genet. 2007; 44(9):556-61.
PMid:17545556 PMCid:PMC2597953
22. Madan K. Balanced complex chromosome rearrangements: reproductive aspects. A review Am J Med Genet A. 2012; 158A(4):947-63.
23. Shao B, Cheng Y, Jin K. Estrogen, neuroprotection and neurogenesis after ischemic stroke. Curr. Drug Targets. 2012; 13(2):188-98.
24. Wang L, Zhang Z, Wang Y, et al. Treatment of stroke with erythropoietin enhances neurogenesis and angiogenesis and improves neurological function in rats. Stroke. 2004; 35(7):1732-7.
25. Mezey E, Chandross K. J, Harta G, et al. Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow. Science. 2000; 290(5497):1779-82.
26. Willing A. E, Lixian J, Milliken M, et al. Intravenous versus intrastriatal cord blood administration in a rodent model of stroke. J Neurosci Res. 2003; 73(3):296-307.
27. Pagani M, Manouilenko I, Stone-Elander S, et al. Brief Report: alterations in cerebral blood flow as assessed by PET/CT in adults with autism spectrum disorder with normal IQ. J Autism Dev Disord. 2012; 42(2):313-8.
28. Rumsey JM, Ernst M. Functional neuroimaging of autistic disorders. Ment Retard Dev Disabil Res Rev. 2000; 6(3):171-9.<171::AID-MRDD4>3.0.CO;2-N
29. Chugani DC. Neuroimaging and neurochemistry of autism. Pediatr Clin North Am. 2012; 59(1):63-73.
30. Sharma A, Gokulchandran N, Sane H, et al. Autologous bone marrow mononuclear cell therapy for autism: an open label proof of concept study. Stem Cells Int. 2013; ID 623875.
31. Scheck S, Boyd R, Rose S. New insights into the pathology of white matter tracts in cerebral palsy from diffusion magnetic resonance imaging: A systematic review. Dev Med Child Neurol. 2012; 54:684–96.
32. Lichtenwalner RJ, Parent JM. Adult neurogenesis and the ischemic forebrain. J Cereb Blood Flow Metab. 2006; 26(1):1-20.

Jae Sun Shim, Kyounghoon Min, MinYoung Kim. Allogenic umbilical cord blood transplantation for a child with chromosomal abnormality: a case report. Cell and Organ Transplantology. 2013; 1(1):19-23. doi: 10.22494/COT.V1I1.53


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