Allogenic umbilical cord blood transplantation for a child with chromosomal abnormality: a case report

Home/2013, Vol. 1, No. 1/Allogenic umbilical cord blood transplantation for a child with chromosomal abnormality: a case report

Cell and Organ Transplantology. 2013; 1(1): 19-23.
DOI: 10.22494/COT.V1I1.44

Allogenic umbilical cord blood transplantation for a child with chromosomal abnormality: a case report

Jae Sun Shim, Kyounghoon Min, MinYoung Kim
CHA Bundang Medical Center, CHA University, Seongnam-si, Republic of Korea

Abstract
A quite number of patients with global developmental delay (GDD) or mental retardation (MR) have chromosomal abnormalities. Comprehensive rehabilitation therapy helps improve the clinical functions of the patients, but there is no fundamental treatment option for GDD or MR. Umbilical cord blood transplantation (UCBT) showed its safety and efficacy through a lot of animal studies and some clinical trials to date. Erythropoietin (EPO) is an option for adjunctive therapy when combined with cell therapy. We treated a child who had GDD and complex chromosome rearrangement with an allogenic UCBT and concurrent EPO injections, and observed clinical improvements, and confirmed the safety of the procedure.

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1. Majnemer A, Shevell M. I. Diagnostic yield of the neurologic assessment of the developmentally delayed child. J Pediatr. 1995; 127(2):193-9.
https://doi.org/10.1016/S0022-3476(95)70294-6
2. Moeschler JB, Shevell M. American Academy of Pediatrics Committee on G. Clinical genetic evaluation of the child with mental retardation or developmental delays. Pediatrics. 2006; 117(6):2304-16.
https://doi.org/10.1542/peds.2006-1006
PMid:16740881
3. Tirosh E, Jaffe M. Global developmental delay and mental retardation–a pediatric perspective. Dev Disabil Res Rev. 2011; 17(2):85-92.
https://doi.org/10.1002/ddrr.1103
PMid:23362028
4. Vendrame M, Cassady J, Newcomb J, et al. Infusion of human umbilical cord blood cells in a rat model of stroke dose-dependently rescues behavioral deficits and reduces infarct volume. Stroke. 2004; 35(10):2390-5.
https://doi.org/10.1161/01.STR.0000141681.06735.9b
PMid:15322304
5. Nan Z, Grande A, Sanberg CD, et al. Infusion of human umbilical cord blood ameliorates neurologic deficits in rats with hemorrhagic brain injury. Ann NY Acad Sci. 2005; 1049:84-96.
https://doi.org/10.1196/annals.1334.009
PMid:15965109
6. Lu D, Sanberg P. R, Mahmood A, et al. Intravenous administration of human umbilical cord blood reduces neurological deficit in the rat after traumatic brain injury. Cell Transplant. 2002; 11(3):275-81.
PMid:12075993
7. Nikolic W. V, Hou H, Town T, et al. Peripherally administered human umbilical cord blood cells reduce parenchymal and vascular beta-amyloid deposits in Alzheimer mice. Stem Cells Dev. 2008; 17(3):423-39.
https://doi.org/10.1089/scd.2008.0018
PMid:18366296 PMCid:PMC2649688
8. Dusing SC, Thorpe DE, Poe MD, et al. Gross motor development of children with hurler syndrome after umbilical cord blood transplantation. Phys Ther. 2007; 87(11):1433-40.
https://doi.org/10.2522/ptj.20070017
PMid:17785373
9. Escolar ML, Poe MD, Martin HR, et al. A staging system for infantile Krabbe disease to predict outcome after unrelated umbilical cord blood transplantation. Pediatrics. 2006; 118(3):e879-89.
https://doi.org/10.1542/peds.2006-0747
PMid:16923928
10. Asadi B, Askari GR, Khorvash F, et al. Neuroprotective effects of erythropoietin in acute ischemic stroke. Int J Prev Med. 2013; 4(Suppl 2):S306-12.
PMid:23776743 PMCid:PMC3678237
11. Mammis A, McIntosh TK.Maniker A. H. Erythropoietin as a neuroprotective agent in traumatic brain injury. Review Surg Neurol. 2009; 71(5):527-31.
https://doi.org/10.1016/j.surneu.2008.02.040
PMid:18789503
12. Iwai M, Cao G, Yin W, et al. Erythropoietin promotes neuronal replacement through revascularization and neurogenesis after neonatal hypoxia/ischemia in rats. Stroke. 2007; 38(10):2795-803.
https://doi.org/10.1161/STROKEAHA.107.483008
PMid:17702962
13. Koh SH, Noh MY, Cho GW, et al. Erythropoietin increases the motility of human bone marrow-multipotent stromal cells (hBM-MSCs) and enhances the production of neurotrophic factors from hBM-MSCs. Stem Cells Dev. 2009; 18(3):411-21.
https://doi.org/10.1089/scd.2008.0040
PMid:18590375
14. Min K, Song J, Kang JY, et al. Umbilical cord blood therapy potentiated with erythropoietin for children with cerebral palsy: a double-blind, randomized, placebo-controlled trial. Stem Cells. 2013; 31(3):581-91.
https://doi.org/10.1002/stem.1304
PMid:23281216 PMCid:PMC3744768
15. Rubinstein P, Dobrila L, Rosenfield RE, et al. Processing and cryopreservation of placental/umbilical cord blood for unrelated bone marrow reconstitution. Proc Natl Acad Sci USA. 1995; 92(22):10119-22.
https://doi.org/10.1073/pnas.92.22.10119
PMid:7479737 PMCid:PMC40747
16. Min K, Yu S, Lee J, et al. Reliability of Fractional Anisotropy Measurement for Children with Cerebral Palsy. Neuropediatrics. 2013; in publishing.
17. Pai GS, Thomas GH, Mahoney W, et al. Complex chromosome rearrangements. Report of a new case and literature review. Clin Genet. 1980; 18(6):436-44.
https://doi.org/10.1111/j.1399-0004.1980.tb01790.x
PMid:7449183
18. Madan K. What is a complex chromosome rearrangement?. Am J Med Genet A. 2013; 161A(5):1181-4.
https://doi.org/10.1002/ajmg.a.35834
PMid:23532917
19. Monfort S, Blesa D, Rosello M, et al. Duplication of 14q11.2 associates with short stature and mild mental retardation: a putative relation with quantitative trait loci. Am J Med Genet A. 2007; 143(4):382-4.
https://doi.org/10.1002/ajmg.a.31608
PMid:17230491
20. Moortgat S, Verellen-Dumoulin C, Maystadt I, et al. Developmental delay and facial dysmorphism in a child with an 8.9 Mb de novo interstitial deletion of 3q25.1-q25.32: Genotype-phenotype correlations of chromosome 3q25 deletion syndrome. Eur J Med Genet. 2011; 54(2):177-80.
https://doi.org/10.1016/j.ejmg.2010.11.011
PMid:21167329
21. Zahir F, Firth HV, Baross A, et al. Novel deletions of 14q11.2 associated with developmental delay, cognitive impairment and similar minor anomalies in three children. J Med Genet. 2007; 44(9):556-61.
https://doi.org/10.1136/jmg.2007.050823
PMid:17545556 PMCid:PMC2597953
22. Madan K. Balanced complex chromosome rearrangements: reproductive aspects. A review Am J Med Genet A. 2012; 158A(4):947-63.
https://doi.org/10.1002/ajmg.a.35220
PMid:22383246
23. Shao B, Cheng Y, Jin K. Estrogen, neuroprotection and neurogenesis after ischemic stroke. Curr. Drug Targets. 2012; 13(2):188-98.
https://doi.org/10.2174/138945012799201702
24. Wang L, Zhang Z, Wang Y, et al. Treatment of stroke with erythropoietin enhances neurogenesis and angiogenesis and improves neurological function in rats. Stroke. 2004; 35(7):1732-7.
https://doi.org/10.1161/01.STR.0000132196.49028.a4
PMid:15178821
25. Mezey E, Chandross K. J, Harta G, et al. Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow. Science. 2000; 290(5497):1779-82.
https://doi.org/10.1126/science.290.5497.1779
PMid:11099419
26. Willing A. E, Lixian J, Milliken M, et al. Intravenous versus intrastriatal cord blood administration in a rodent model of stroke. J Neurosci Res. 2003; 73(3):296-307.
https://doi.org/10.1002/jnr.10659
PMid:12868063
27. Pagani M, Manouilenko I, Stone-Elander S, et al. Brief Report: alterations in cerebral blood flow as assessed by PET/CT in adults with autism spectrum disorder with normal IQ. J Autism Dev Disord. 2012; 42(2):313-8.
https://doi.org/10.1007/s10803-011-1240-y
PMid:21487836
28. Rumsey JM, Ernst M. Functional neuroimaging of autistic disorders. Ment Retard Dev Disabil Res Rev. 2000; 6(3):171-9.
https://doi.org/10.1002/1098-2779(2000)6:3<171::AID-MRDD4>3.0.CO;2-N
29. Chugani DC. Neuroimaging and neurochemistry of autism. Pediatr Clin North Am. 2012; 59(1):63-73.
https://doi.org/10.1016/j.pcl.2011.10.002
PMid:22284793
30. Sharma A, Gokulchandran N, Sane H, et al. Autologous bone marrow mononuclear cell therapy for autism: an open label proof of concept study. Stem Cells Int. 2013; ID 623875.http://dx.doi.org/10.1155/2013/623875.
https://doi.org/10.1155/2013/623875
31. Scheck S, Boyd R, Rose S. New insights into the pathology of white matter tracts in cerebral palsy from diffusion magnetic resonance imaging: A systematic review. Dev Med Child Neurol. 2012; 54:684–96.
https://doi.org/10.1111/j.1469-8749.2012.04332.x
PMid:22646844
32. Lichtenwalner RJ, Parent JM. Adult neurogenesis and the ischemic forebrain. J Cereb Blood Flow Metab. 2006; 26(1):1-20.
https://doi.org/10.1038/sj.jcbfm.9600170
PMid:15959458

Jae Sun Shim, Kyounghoon Min, MinYoung Kim. Allogenic umbilical cord blood transplantation for a child with chromosomal abnormality: a case report. Cell and Organ Transplantology. 2013; 1(1):19-23. doi: 10.22494/COT.V1I1.53

 

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