Umbilical cord stem cells: biological characteristics, approaches to banking and clinical application

Home/2016, Vol. 4, No. 2/Umbilical cord stem cells: biological characteristics, approaches to banking and clinical application

Cell and Organ Transplantology. 2016; 4(2):230-235.
DOI: 10.22494/COT.V4I2.61

Umbilical cord stem cells: biological characteristics, approaches to banking and clinical application

Nasadyuk C. M.
Institute of Cell Therapy, Kyiv, Ukraine

Abstract
Due to the prominent immunosuppressive and regenerative properties, umbilical cord mesenchymal stem cells are the most widely explored in the treatment of autoimmune diseases and posttransplant complications as well as for the facilitation of engraftment of hematopoietic stem cell transplant and cell culturing in vitro. The review presents modern immunophenotypic characterization of the umbilical cord mesenchymal stem cells, approaches to isolation, biobanking, and clinical application.

Key words: umbilical cord; mesenchymal stem cells; cell therapy; biobanking

 

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1. Nagamura-Inoue T, He H. Umbilical cord-derived mesenchymal stem cells: Their advantages and potential clinical utility. World J Stem Cells. 2014; 6(2):95-202.
https://doi.org/10.4252/wjsc.v6.i2.195
PMid:24772246 PMCid:PMC3999777
2. Nasadyuk CM, Makhinya AV, Zak SO, et al. Current status and perspectives of cryostorage and clinical application of the umbilical cord blood in Ukraine and in the World. Cell and organ Transplantology. 2015; 3(2):214-219.
https://doi.org/10.22494/cot.v3i2.24
3. Overview of the World congress on cord blood and innovative approaches to the treatment of sickle-cell anemia in Monaco on 24-27 October 2013. Cell and organ Transplantology. 2014; 2(1):95-101.
4. Ding DC, Chang YH, Shyu WC, et al. Human Umbilical Cord Mesenchymal Stem Cells: A New Era for Stem Cell Therapy. Cell Transplant. 2015; 24(3):339-347.
https://doi.org/10.3727/096368915X686841
PMid:25622293
5. Cooper K, Shah V, Sapre N, et al. Defining Permissible Time Lapse between Umbilical Cord Tissue Collection and Commencement of Cell Isolation. Int J Hematol Oncol Stem Cell Res. 2013; 7(4):15-23.
PMid:24505538 PMCid:PMC3915426
6. Review of reports of the 13th meeting of the International Society for Stem Cell Research – ISSCR (24-27 June 2015, Stockholm, Sweden). Cell and organ Transplantology. 2015; 3(2):224-26.
7. Petrou IG, Grognuz A, Hirt-Burri N, et al. Cell therapies or tendons: old cell choice for modern innovation. Swiss Med Wkly. 2014; 7:144:w13989.
8. Ullah I, Subbarao RB, Gyu JR. Human mesenchymal stem cells – current trends and future prospective. Biosci Rep. 2015; 35(2):e00191.
https://doi.org/10.1042/BSR20150025
PMid:25797907 PMCid:PMC4413017
9. Chen JY, Mou XZ, Du XC, et al. Comparative analysis of biological characteristics of adult mesenchymal stem cells with different tissue origins. Asian Pac J Trop Med. 2015; 8(9):739-46.
https://doi.org/10.1016/j.apjtm.2015.07.022
PMid:26433660
10. Bourget JM, Gauvin R, Duchesneau D, et al. Potential of Newborn and Adult Stem Cells for the Production of Vascular Constructs Using the Living Tissue Sheet Approach. Biomed Res Int. 2015; 2015:168294.
https://doi.org/10.1155/2015/168294
PMid:26504783 PMCid:PMC4609342
11. Cardoso TC, Ferrari HF, Garcia AF. Isolation and characterization of Wharton’s jelly-derived multipotent mesenchymal stromal cells obtained from bovine umbilical cord and maintained in a defined serum-free three-dimensional system. BMC Biotechnol. 2012; 4(12):P18.
https://doi.org/10.1186/1472-6750-12-18
PMid:22559872 PMCid:PMC3443425
12. Polchow B, Kebbel K, Schmiedeknecht G, et al. Cryopreservation of human vascular umbilical cord cells under good manufacturing practice conditions for future cell banks. J Transl Med. 2012; 16(10):98.
https://doi.org/10.1186/1479-5876-10-98
PMid:22591741 PMCid:PMC3422199
14. Kadekar D, Kale V, Limaye L. Differential ability of MSCs isolated from placenta and cord as feeders for supporting ex vivo expansion of umbilical cord blood derived CD34(+) cells. Stem Cell Res Ther. 2015; 19(6):201.
https://doi.org/10.1186/s13287-015-0194-y
PMid:26481144 PMCid:PMC4617445
15. Briddell R, Litkenhaus F, Foertsch G, et al. Recovery of viable MSCs isolated from fresh umbilical cord tissue, measured after cryopreservation, is on average 8-fold higher when compared to recovery of viable MSCs isolated from previously cryopreserved umbilical cord tissue. Blood (ASH Annual Meeting Abstracts). 2011; 118:Abstract 4398.
16. http://parentsguidecordblood.org
17. www.clinicaltrials.gov
18. Nasadyuk CM. Stem Cell Therapy In The Treatment Of Inflammatory Bowel Disease. Gastroenterology&Hepatology: Open Access. 2014; 1(1):00006.
19. El-Jawhari JJ, El-Sherbiny YM, Jones EA, et al. Mesenchymal stem cells, autoimmunity and rheumatoid arthritis. QJM. 2014; 107(7):505-14.
https://doi.org/10.1093/qjmed/hcu033
PMid:24518000 PMCid:PMC4071294
20. Li-Xue G, Hui G, hai-Bo L, et al. Therapeutic efficacy of umbilical cord-derived mesenchymal stem cells in patients with type 2 diabetes. Experimental and Therapeutic Medicine. 2015; 9:1623-30.
21. Zuo D, Liu X, Shou Z, et al. Study on the interactions between transplanted bone marrow-derived mesenchymal stem cells and regulatory T cells for the treatment of experimental colitis. Int J Mol Med. 2013; 32(6):1337-44.
PMid:24142133
22. de Miguel MP, Fuentes-Julián S, Blázquez-Martínez A, et al. Immunosuppressive properties of mesenchymal stem cells: advances and applications. Curr Mol Med. 2012; 12(5):574-91.
https://doi.org/10.2174/156652412800619950
PMid:22515979
23. Hayashi Y, Tsuji S, Tsuji M, et al. Topical implantation of mesenchymal stem cells has beneficial effects on healing of experimental colitis in rats. J Pharmacol Exp Ther. 2008; 326(2):523-31.
https://doi.org/10.1124/jpet.108.137083
PMid:18448866
24. Wang L, Cong X, Liu G, et al. Human umbilical cord mesenchymal stem cell therapy for patients with active rheumatoid arthritis: safety and efficacy. Stem Cells Dev. 2013; 22(24):3192-3202.
https://doi.org/10.1089/scd.2013.0023
PMid:23941289
25. Li L, Liu S, Xu Y, et al. Human umbilical cord-derived mesenchymal stem cells downregulate inflammatory responses by shifting the Treg/Th17 profile in experimental colitis. Pharmacology. 2013; 92(5-6):257-64.
https://doi.org/10.1159/000354883
PMid:24280970
26. Nasadyuk CM. Cell Therapy in Gastroenterology. Cell and Organ Transplantology. 2015; 3(1):78-81.
https://doi.org/10.22494/cot.v3i1.25
27. Voswinkel J, Francois S, Gorin NC, et al. Gastro-intestinal autoimmunity: preclinical experiences and successful therapy of fistulizing bowel diseases and gut graft versus host disease by mesenchymal stromal cells. Immunol Res. 2013; 56(2-3):241-48.
https://doi.org/10.1007/s12026-013-8397-8
PMid:23564182
28. Deng X, Szabo S, Chen L, et al. New cell therapy using bone marrow-derived stem cells/endothelial progenitor cells to accelerate neovascularization in healing of experimental ulcerative colitis. Curr Pharm. Des. 2011; 17(16):1643-51.
https://doi.org/10.2174/138161211796197007
PMid:21548863
29. van Deen WK, Oikonomopoulos A, Hommes DW. Stem cell therapy in inflammatory bowel disease: which, when and how. Curr Opin Gastroenterol. 2013; 29(4):384-390.
https://doi.org/10.1097/MOG.0b013e328361f763
PMid:23666365
30. Wang D, Li J, Zhang Y, et al. Umbilical cord mesenchymal stem cell transplantation in active and refractory systemic lupus erythematosus: a multicenter clinical study. Arthritis Res Ther. 2014; 16(2):R79.
https://doi.org/10.1186/ar4520
PMid:24661633 PMCid:PMC4060570
31. Chen T, Zhang P, Fan W, et al. Co-transplantation with mesenchymal stem cells expressing a SDF-1/HOXB4 fusion protein markedly improves hematopoietic stem cell engraftment and hematogenesis in irradiated mice. Umbilical Cord-Derived Mesenchymal Stem Cells for Hematopoietic Stem Cell Transplantation. Am J Transl Res. 2014; 6(6):691-702.
PMid:25628780 PMCid:PMC4297337
32. van der Garde M, van Pel M, Millán Rivero JE, et al. Direct Comparison of Wharton’s Jelly and Bone Marrow-Derived Mesenchymal Stromal Cells to Enhance Engraftment of Cord Blood CD34(+) Transplants. Stem Cells Dev. 2015; 24(22):2649-59.
https://doi.org/10.1089/scd.2015.0138
PMid:26414086 PMCid:PMC4652197
33. Wu KH, Tsai C, Wu HP. Human Application of Ex-Vivo Expanded Umbilical Cord-Derived Mesenchymal Stem Cells: Enhance Hematopoiesis after Cord Blood Transplantation. Cell Transplant. 2013; 22(11):2041-51. doi: 10.3727/096368912X663533
https://doi.org/10.3727/096368912X663533
34. Wu KH, Sheu JN, Wu HP. Cotransplantation of umbilical cord-derived mesenchymal stem cells promote hematopoietic engraftment in cordblood transplantation: a pilot study. Transplantation 2013; 95(5):773-77.
https://doi.org/10.1097/TP.0b013e31827a93dd
PMid:23274973
35. Arufe MC, De la Fuente A, Fuentes I, et al. Umbilical cord as a mesenchymal stem cell source for treating joint pathologies. World J Orthop. 2011; 2(6):43-50.
https://doi.org/10.5312/wjo.v2.i6.43
PMid:22474635 PMCid:PMC3302041
36. Chao Yu-Hua, Wu Han-Ping, Chan Chin-Kan, et al. Umbilical Cord-Derived Mesenchymal Stem Cells for Hematopoietic Stem Cell Transplantation. Hindawi Publishing Corporation Journal of Biomedicine and Biotechnology. 2012; 2012:759503.
37. Kim SW, Jin HL, Kang SM, et al. Therapeutic effects of late outgrowth endothelial progenitor cells or mesenchymal stem cells derived from human umbilical cord blood on infarct repair. Int J Cardiol. 2015; 203:498-507.
https://doi.org/10.1016/j.ijcard.2015.10.110
PMid:26551883
38. Zhao XF, Xu Y, Zhu ZY. Clinical observation of umbilical cord mesenchymal stem cell treatment of severe systolic heart failure. Shi Genet Mol Res. 2015; 14(2):3010-17.
https://doi.org/10.4238/2015.April.10.11
PMid:25966065
39. Yan C, Xue G, Wu L. Differentiation of human umbilical cord mesenchymal stem cells into hepatocytes induced by rat fibrotic liver tissue extracts. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2015; 29(7):878-83.
PMid:26540984
40. Xue HL, Zeng WZ, Wu XL, et al. Clinical therapeutic effects of human umbilical cord-derived mesenchymal stem cells transplantation in the treatment of end-stage liver disease. Transplant Proc. 2015; 47(2):412-18.
https://doi.org/10.1016/j.transproceed.2014.10.048
PMid:25769583
41. Talaei-Khozani T, Borhani-Haghighi M, Ayatollahi M. An in vitro model for hepatocyte-like cell differentiation from Wharton’s jelly derived-mesenchymal stem cells by cell-base aggregates. Gastroenterol Hepatol Bed Bench. 2015; 8(3):188-99.
PMid:26328041 PMCid:PMC4553159
42. Gu J, Gu W, Lin C, et al. Human umbilical cord mesenchymal stem cells improve the immune associated inflammatory and prothrombotic state in collagen type Ⅱ induced arthritic rats. Mol Med Rep. 2015; 12(5):7463-70.
https://doi.org/10.3892/mmr.2015.4394
43. Wang X, Wang Y, Gou W, et al. Role of mesenchymal stem cells in bone regeneration and fracture repair: a review. International Orthopaedics (SICOT). 2013; 37(12):2491-2498.
https://doi.org/10.1007/s00264-013-2059-2
PMid:23948983 PMCid:PMC3843208
44. Pang X, Yang H, Peng B. Human Umbilical Cord Mesenchymal Stem Cell Transplantation for the Treatment of Chronic Discogenic Low Back Pain. Pain Physician. 2014; 17(4):E525-30.
PMid:25054402
45. Hou Z, Liu Y, Mao X, et al. Transplantation of umbilical cord and bone marrow-derived mesenchymal stem cells in a patient with relapsing-remitting multiple sclerosis. Cell Adhesion & Migration. 2013; 7(5):404-07.
https://doi.org/10.4161/cam.26941
PMid:24192520 PMCid:PMC3903683
46. Cheng H, Liu X, Hua R, et al. Clinical observation of umbilical cord mesenchymal stem cell transplantation in treatment for sequelae of thoracolumbar spinal cord injury. J Transl Med. 2014; 12:253.
https://doi.org/10.1186/s12967-014-0253-7
PMid:25209445 PMCid:PMC4172930
47. Song L, Zhu J, Zhang X, et al. BDNF-hypersecreting human umbilical cord blood mesenchymal stem cells promote erectile function in a rat model of cavernous nerve electrocautery injury. Int Urol Nephrol. 2016; 48(1):37-45.
https://doi.org/10.1007/s11255-015-1154-2
PMid:26577999
48. Oh EJ, Kim TK, Shin JH, et al. Biologic filler using human fibroblasts and placenta extracts. J Craniofac Surg. 2011; 22(5):1557-60.
https://doi.org/10.1097/SCS.0b013e31822e5c5e
PMid:21959386
49. Li F, Chen YZ, Miao ZN, et al. Human placenta-derived mesenchymal stem cells with silk fibroin biomaterial in the repair of articular cartilage defects. Cell Reprogram. 2012; 14(4):334-41.
PMid:22816556
50. Dominici M, Le Blanc K, Mueller I, et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy. 2006; 8(4):315-17.
https://doi.org/10.1080/14653240600855905
PMid:16923606
51. Wu QL, Liu XY, Nie DM, et al. Umbilical cord blood-derived mesenchymal stem cells ameliorate graft-versus-host disease following allogeneic hematopoietic stem cell transplantation through multiple immunoregulations. J Huazhong Univ Sci Technolog Med Sci. 2015; 35(4):477-84
https://doi.org/10.1007/s11596-015-1456-8
PMid:26223913

Nasadyuk CM. Umbilical cord stem cells: biological characteristics, approaches to banking and clinical application. Cell and Organ Transplantology. 2016; 4(2):230-235. doi:10.22494/cot.v4i2.61

 

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