The biological properties of cancer stem cells in malignant gliomas in tissue culture: a review

Home/2015, Vol. 3, No. 2/The biological properties of cancer stem cells in malignant gliomas in tissue culture: a review

Cell and Organ Transplantology. 2015; 3(2):163-168.
DOI: 10.22494/COT.V3I2.12

The biological properties of cancer stem cells in malignant gliomas in tissue culture: a review

Semenova V. M., Lisyany N. I., Rosumenko V. D., Egorova D. M., Staino L. P.
A. P. Romodanov State Institute of Neurosurgery NAMS of Ukraine, Kyiv, Ukraine

This review presents recent data on the biological properties of cancer stem cells in brain gliomas. The possibilities of using of experimental methods of cell culture and immunohistochemical identification of tumor stem cells as a part of neurospheres (tumorospheres) are shown. Methodological features of neurospheres culture are described.
Literature data about the dependence of neurospheres formation activity in the culture on the degree of anaplasia of original glioma tissues are presented considering the disease outcomes in neuro-oncological patients. Possibilities of the practical use of cultured tumorospheres in the study of selective impact of antiblastic drugs on tumor stem cells in gliomas are described.

Key words: cancer stem cells, glioma, cell culture, neurosphere

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Semenova VM, Lisyany NI, Rosumenko VD, Egorova DM, Staino LP. The biological properties of cancer stem cells in malignant gliomas in tissue culture: a review. Cell and Organ Transplantology. 2015; 3(2):163-168. doi: 10.22494/COT.V3I2.12


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