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Stem cell therapy helps broken hearts heal in unexpected way

A study shows stem cell therapy helps hearts recover from a heart attack, although not for the biological reasons originally proposed two decades ago that today are the basis of ongoing clinical trials. The study reports that injecting living or even dead heart stem cells into the injured hearts of mice triggers an acute inflammatory process, which in turn generates a wound healing-like response to enhance the mechanical properties of the injured area.

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Tendon stem cells could revolutionize injury recovery

The buildup of scar tissue makes recovery from torn rotator cuffs, jumper’s knee, and other tendon injuries a painful, challenging process, often leading to secondary tendon ruptures. New research reveals the existence of tendon stem cells that could potentially be harnessed to improve tendon healing and even to avoid surgery.

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New method to purify cell types to high purity

Current biology research relies on the ability to purify cell types using antibodies or transgenic constructs. However, antibody availability is often limited, and genetic manipulation is labor intensive or sometimes impossible. To date, no universal method exists to enrich for cell types without a priori knowledge of cell type markers. Here, we propose GateID, a computational method that combines single-cell transcriptomics with FACS index sorting to purify cell types using only native cellular properties.

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Potential liver cancer treatment by targeting cancer stem-like cells

Liver cancer is the second leading cause of cancer-related deaths worldwide. The most common primary liver cancer in adults is known as hepatocellular carcinoma (HCC), and accounts for approximately 780,000 deaths every year. Even with advanced surgical treatments or transplantation, the 5-year survival rate for HCC patients remains poor due to frequent recurrence.

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Transient wave of hematopoietic stem cell production in late fetuses and young adults

A major challenge in regenerative medicine is producing tailor-made hematopoietic stem cells (HSCs) for transplantation. For this we need a better understanding of where, when and how HSCs are produced in vivo. Scientists have now discovered a new hematopoietic wave in the bone marrow that fills the gap between embryonic blood production and adult bone marrow hematopoietic production.

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How time affects the fate of stem cells

How do temporal variations in protein concentrations affect biology? It’s a question that biologists have only recently begun to address, and the findings are increasingly showing that random temporal changes in the amount of certain proteins play a direct and significant role on biological processes.

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