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Mini kidneys grown from stem cells give new insights into kidney disease and therapies

Medical researchers have grown ‘miniature kidneys’ in the laboratory that could be used to better understand how kidney diseases develop in individual patients. These kidney organoids were grown outside the body from skin cells derived from a single patient who has polycystic kidney disease. This method has paved the way for tailoring treatment plans specific to each patient, which could be extended to a range of kidney diseases.

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Novel dual stem cell therapy improving cardiac regeneration

Researchers have recently developed a multipronged approach for concurrently rejuvenating both the muscle cells and vascular systems of the heart by utilizing two types of stem cells. The findings give hope to develop a new treatment for repairing hearts damaged by myocardial infarction, as an alternative to heart transplant.

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Repair of aged tissue can be enhanced by inhibiting signals from neighboring cells

Researchers have discovered how regenerative capacity of intestinal epithelium declines when we age. Targeting of an enzyme that inhibits stem cell maintaining signaling rejuvenates the regenerative potential of an aged intestine. This finding may open ways to alleviate age-related gastrointestinal problems, reduce side-effects of cancer treatments, and reduce healthcare costs in the ageing society by promoting recovery.

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