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Insulin-producing pancreatic cells created from human skin cells

Scientists at the Gladstone Institutes and the University of California, San Francisco (UCSF) have successfully converted human skin cells into fully-functional pancreatic cells. The new cells produced insulin in response to changes in glucose levels, and, when transplanted into mice, the cells protected the animals from developing diabetes in a mouse model of the disease.

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A new porous hydrogel could boost the success of stem-cell-based tissue regeneration

Stem cell therapies are often limited by low survival of transplanted stem cells and the lack of precise control over their differentiation into the terminal cell types needed to repair or replace injured tissues. Now, a team led by Wyss Institute Core Faculty member David Mooney, Ph.D., has developed a new strategy – embedding stem cells into porous, transplantable hydrogels – that has experimentally improved bone repair by boosting the survival rate of transplanted stem cells and influencing their cell differentiation.

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Control Embryonic Stem Cells With Light

UC San Francisco researchers have for the first time developed a method to precisely control embryonic stem cell differentiation with beams of light, enabling them to be transformed into neurons in response to a precise external cue.

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Hybrid hepatocytes regenerate the liver without giving rise to cancer

A new study has revealed a previously unidentified group of cells that can regenerate liver tissue without forming tumors. Previously, researchers believed that a group of adult stem cells known as oval cells were responsible for the liver’s renowned regenerative properties, but it has since been proven that these stem cells develop into bile duct cells.

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