Our body makes antibodies to fight infections. But the synthetic versions of these molecules could hold the key to stimulating the body’s ability to regenerate.
The development of new bone can be a multistep process: first, stem cells differentiate into cartilage cells. Next, the cartilage cells become bone cells. But that’s not all: the cells must experience some mechanical stresses during the transformation in order to transform efficiently from stem cells to bone cells.
Scientists have created miniature brains from stem cells that developed functional neural networks. Despite being a million times smaller than human brains, these lab-grown brains are the first observed to produce brain waves that resemble those of preterm babies.
Medical researchers have grown ‘miniature kidneys’ in the laboratory that could be used to better understand how kidney diseases develop in individual patients. These kidney organoids were grown outside the body from skin cells derived from a single patient who has polycystic kidney disease. This method has paved the way for tailoring treatment plans specific to each patient, which could be extended to a range of kidney diseases.
Scientists say the results have far reaching implications for how we understand the aging process, and how we might develop much-needed treatments for age-related brain diseases.
Researchers have recently developed a multipronged approach for concurrently rejuvenating both the muscle cells and vascular systems of the heart by utilizing two types of stem cells. The findings give hope to develop a new treatment for repairing hearts damaged by myocardial infarction, as an alternative to heart transplant.
Japanese scientists have developed an efficient method of successfully generating hair growth in nude mice. The new method can be scaled up and therefore shows great potential for clinical applications in human hair regenerative therapy.
Researchers at King’s College London have used single cell RNA sequencing to identify a type of cell that may be able to regenerate liver tissue, treating liver failure without the need for transplants.
A phase I clinical trial is the first research monitored by the Food and Drug Administration that demonstrates the potential of regenerative therapy for hypoplastic left heart syndrome (HLHS) through collecting, processing and injecting an infant’s own stem cells directly into the heart at the time of surgery.
Researchers have discovered how regenerative capacity of intestinal epithelium declines when we age. Targeting of an enzyme that inhibits stem cell maintaining signaling rejuvenates the regenerative potential of an aged intestine. This finding may open ways to alleviate age-related gastrointestinal problems, reduce side-effects of cancer treatments, and reduce healthcare costs in the ageing society by promoting recovery.