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Taking miniature organs from lab to clinic

Scientists have developed a gel for growing miniaturized body organs that can be used in clinical diagnostics and drug development. Organoids are miniature organs that can be grown in the lab from a person’s stem cells. They can be used to model diseases, and in the future could be used to test drugs or even replace damaged tissue in patients.

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Rebooting the immune system: Blood stem cells in multiple sclerosis therapy

As part of an international clinical trial, researchers at the Sheffield Teaching Hospital recently reported interesting developments in multiple sclerosis therapy. Using the patients’ own blood stem cells, the scientists were able to reboot their immune system, therefore preventing autoreactive immune cells from further attacks on their fragile nervous system.

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5-й зʼїзд Українського товариства клітинної біології

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5-й зʼїзд Українського товариства клітинної біології з міжнародним представництвом
До уваги фахівців у галузі клітинної біології, мікробіології, молекулярної біології, біотехнології, імунології.

ІНФОРМАЦІЙНЕ ПОВІДОМЛЕННЯ

Всеукраїнська громадська організація “Українське товариство клітинної біології”, Інститут біології клітини НАН України повідомляють, що 02.10.2016 ‐ 06.10.2016 у м.Одеса на базі Одеського національного університету ім. І. Мечнікова за підтримки Національної академії наук України (НАН України) відбудеться черговий, 5-й зʼїзд Українського товариства клітинної біології з міжнародним представництвом (International Symposium on Cell Biology jointly with 5th Ukrainian Congress for Cell Biology).

Fertility genes required for sperm stem cells

The underlying cause of male infertility is unknown for 30 percent of cases. In a pair of new studies, researchers at University of California San Diego School of Medicine determined that the reproductive homeobox (RHOX) family of transcription factors — regulatory proteins that activate some genes and inactivate others — drive the development of stem cells in the testes in mice. The investigators also linked RHOX gene mutations to male infertility in humans. The mouse study is published September 27 by Cell Reports and the human study was published September 15 byHuman Molecular Genetics.

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Researchers shed light on repair mechanism for severe corneal injuries

In cases of severe ocular trauma involving the cornea, wound healing occurs following intervention, but at the cost of opaque scar tissue formation and damaged vision. Recent research has shown that mesenchymal stem cells (MSCs) — which can differentiate into a variety of cells, including bone, cartilage, muscle and fat cells — are capable of returning clarity to scarred corneas; however, the mechanisms by which this happens remained a mystery — until now. In a study published online today in Stem Cell Reports, researchers from Schepens Eye Research Institute of Massachusetts Eye and Ear have identified hepatocyte growth factor (HGF), secreted by MSCs, as the key factor responsible for promoting wound healing and reducing inflammation in preclinical models of corneal injury. Their findings suggest that HGF-based treatments may be effective in restoring vision in patients with severely scarred corneas.

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Functional human tissue-engineered liver generated from stem, progenitor cells

A research team led by investigators at The Saban Research Institute of Children’s Hospital Los Angeles has generated functional human and mouse tissue-engineered liver from adult stem and progenitor cells. Tissue-engineered Liver (TELi) was found to contain normal structural components such as hepatocytes, bile ducts and blood vessels. The study has been published online in the journalStem Cells Translational Medicine.

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