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Transplanted neurons incorporated into a stroke-injured rat brain

Today, a stroke usually leads to permanent disability – but in the future, the stroke-injured brain could be reparable by replacing dead cells with new, healthy neurons, using transplantation. Researchers have taken a step in that direction by showing that some neurons transplanted into the brains of stroke-injured rats were incorporated and responded correctly when the rat’s muzzle and paws were touched. 

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Stem cell therapy reverses blindness in animals with end-stage retinal degeneration

A stem cell-based transplantation approach that restores vision in blind mice moves closer to being tested in patients with end-stage retinal degeneration, according to a study. The researchers showed that retinal tissue derived from mouse induced pluripotent stem cells (iPSCs) established connections with neighboring cells and responded to light stimulation after transplantation into the host retina, restoring visual function in half of mice with end-stage retinal degeneration.

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Scientists tissue-engineer functional part of human stomach in laboratory

Scientists have used pluripotent stem cells to generate human stomach tissues in a Petri dish that produce acid and digestive enzymes. They grew tissues from the stomach’s corpus/fundus region. The study comes two years after the same team generated the stomach’s hormone-producing region (the antrum). The discovery means investigators now can grow both parts of the human stomach to study disease.

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Therapy response in brain tumor cells is linked to disease prognosis

The brain tumor form glioblastoma is difficult to treat and has very poor prognosis. In a new study, scientists show that a type of stem cell in the tumor is present in different states, with different response to drugs and radiation. The results may open an avenue towards development of new treatment strategies designed to reverse therapy resistant cell states to more sensitive states.

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