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Rebooting the immune system: Blood stem cells in multiple sclerosis therapy

As part of an international clinical trial, researchers at the Sheffield Teaching Hospital recently reported interesting developments in multiple sclerosis therapy. Using the patients’ own blood stem cells, the scientists were able to reboot their immune system, therefore preventing autoreactive immune cells from further attacks on their fragile nervous system.

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Regeneration of spinal nerve cells boosted

UT Southwestern Medical Center researchers successfully boosted the regeneration of mature nerve cells in the spinal cords of adult mammals — an achievement that could one day translate into improved therapies for patients with spinal cord injuries.

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International Symposium on Cell Biology jointly with 5th Ukrainian Congress for Cell Biology

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International Symposium on Cell Biology jointly with 5th Ukrainian Congress for Cell Biology
For the attention of specialists in the field of cell biology, microbiology, molecular biology, biotechnology, immunology.

Institute of Cell Biology National Academy of Sciences of Ukraine, All-Ukrainian Public Organization “Ukrainian Society of Cell Biology” inform you about:

International Symposium on Cell Biology jointly with 5th Ukrainian Congress for Cell Biology that will be held on October 2-6, 2016 in Odesa, Ukraine at the Ilya Mechnikov Odesa National University.

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Fertility genes required for sperm stem cells

The underlying cause of male infertility is unknown for 30 percent of cases. In a pair of new studies, researchers at University of California San Diego School of Medicine determined that the reproductive homeobox (RHOX) family of transcription factors — regulatory proteins that activate some genes and inactivate others — drive the development of stem cells in the testes in mice. The investigators also linked RHOX gene mutations to male infertility in humans. The mouse study is published September 27 by Cell Reports and the human study was published September 15 byHuman Molecular Genetics.

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Researchers shed light on repair mechanism for severe corneal injuries

In cases of severe ocular trauma involving the cornea, wound healing occurs following intervention, but at the cost of opaque scar tissue formation and damaged vision. Recent research has shown that mesenchymal stem cells (MSCs) — which can differentiate into a variety of cells, including bone, cartilage, muscle and fat cells — are capable of returning clarity to scarred corneas; however, the mechanisms by which this happens remained a mystery — until now. In a study published online today in Stem Cell Reports, researchers from Schepens Eye Research Institute of Massachusetts Eye and Ear have identified hepatocyte growth factor (HGF), secreted by MSCs, as the key factor responsible for promoting wound healing and reducing inflammation in preclinical models of corneal injury. Their findings suggest that HGF-based treatments may be effective in restoring vision in patients with severely scarred corneas.

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Functional human tissue-engineered liver generated from stem, progenitor cells

A research team led by investigators at The Saban Research Institute of Children’s Hospital Los Angeles has generated functional human and mouse tissue-engineered liver from adult stem and progenitor cells. Tissue-engineered Liver (TELi) was found to contain normal structural components such as hepatocytes, bile ducts and blood vessels. The study has been published online in the journalStem Cells Translational Medicine.

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Brain cells restored by stem cell therapy following stroke, neurological diseases

When a person has a stroke, blood flow to the brain is interrupted, causing brain cells to die within minutes due to lack of oxygen. In some cases, this can result in paralysis, speech and language problems, vision problems, and memory loss. But in a new study, researchers have shown that stem cell therapy increases nerve cell production in mice with brain damage due to stroke.

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