Current issues of skin aging and strategies for its correction

Cell and Organ Transplantology. 2021; 9(1):68-74.
DOI: 10.22494/cot.v9i1.124

Current issues of skin aging and strategies for its correction

Ivanishchev V.

D. F. Chebotarev State Institute of Gerontology of the National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine

Abstract

The review analyzes current experimental and clinical data on skin aging. One of skin aging phenomena is the aging of its cells. Senescent cells produce a broad spectrum of cytokines that alter the microenvironment of tissues. The results of recent studies show that the microenvironment affects the functional activity of stem cells, which is accompanied by impairment in skin regeneration and recovery.

Keywords: skin aging; skin stem cells; senescent cells; senolytics

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References

1. Araviyskaya ER. Vozrastnye izmeneniya v derme: novye svedeniya i puti korrektsii s pomoshch’yu sredstv dlya ezhednevnogo ukhoda [Age-related changes in the dermis: new information and ways of correction with the help of means for daily care]. Russkiy meditsinskiy zhurnal – Russian medical journal. 2008; 8:574-575. [In Russian]

2. Volkova NA, Mazur SP, Kholodny VS, Petrenko AYu. Stvolovye kletki kozhi kak ob”ekt kriokonservirovaniya [Skin stem cells as an object of cryopreservation]. Problemy kriobiologii i kriomeditsiny – Problems of cryobiology and cryomedicine. 2014; 24(1):3-15. [In Russian] https://doi.org/10.15407/cryo24.01.003

3. Dudinskaya EN, Tkacheva ON, Machekhina LV, Kotovskaya YuV, Leontyeva IV, Kovalev IA, et al. Rol’ insulinorezistentnosti i arterial’noy gipertonii v protsessakh replikativnogo kletochnogo stareniya [The role of insulin resistance and arterial hypertension in the processes of replicative cellular aging]. Arterial’naya gipertenziya – Arterial hypertension. 2019; 25(3):225-231. [In Russian] https://doi.org/10.18705/1607-419X-2019-25-3-225-231

4. Zorina А. Fibroblasty kozhi i effektivnost’ anti – eydzh korrektsii [Skin fibroblasts and the effectiveness of anti-age correction]. Кosmetik international. 2013; 2:14-23. [In Russian]

5. Kalyuzhnaya LD. Starenie kozhi i khronicheskie dermatozy u zhenshchin menopauzal’nogo perioda [Skin aging and chronic dermatoses in menopausal women]. 2006. Available from: https://mazg.com.ua/ru-issue-article-10. [In Russian]

6. Kamalov AA, Okhobotov DA. Stvolovye kletki i ikh ispol’zovanie v sovremennoy klinicheskoy praktike [Stem cells and their use in modern clinical practice]. Urologiya – Urology. 2012; 5:105-114. [In Russian]

7. Kishkun АА. Biologicheskiy vozrast i starenie: vozmozhnosti opredeleniya i puti korrektsii. [Biological age and aging: possibilities of definition]. Ruk-vo dlya vrachey – Manual for doctors. Moskva: GEOTAR-Media, 2008. 973 p. [In Russian]

8. Malygina NA. Starenie kletok i vozrastzavisimye zabolevaniya [Cell aging and age-related diseases]. Klinicheskaya gerontologiya – Clinical gerontology. 2014; 3-4:30-34. [In Russian]

9. Moskalev AA. Rol’ stvolovoy nishi v protsessakh stareniya organizma [The role of the stem niche in the aging process of the body]. Ros Khim Zhurnal – Rus Chem J. 2009; 53(3):83-87. [In Russian]

10. Paltsyn AA. Senolitiki. Patogenez [Senolytics. Pathogenesis]. 2019; 17(4):78-84. [In Russian] https://doi.org/10.25557/2310-0435.2019.04.78-84

11. Ruksha TG, Aksenenko MB, Klimina GM, Novikova LV. Vnekletochnyy matriks kozhi: rol’ v razvitii dermatologicheskikh zabolevaniy [Extracellular matrix of the skin: role in the development of dermatological diseases]. Vestnik dermatologii i venerologii – Bulletin of Dermatology and Venereology. 2013; 6:32-39. [In Russian]

12. Shirshakova M. Klinicheskaya effektivnost’ stimulyatsii kozhi preparatami nativnoy gialuronovoy kisloty v zerkale instrumentel’noy diagnostiki [Clinical efficacy of skin stimulation with preparations of native hyaluronic acid in the mirror of instrumental diagnostics]. In”ektsionnye metody v kosmetologii – Injection methods in cosmetology. 2010; 3:74-81. [In Russian]

13. Abad M, Mosteiro L, Pantoja C, Cañamero M, Rayon T, Ors I, et al. Reprogramming in vivo produces teratomas and iPS cells with totipotency features. Nature. 2013; 502(7471):340-5. https://doi.org/10.1038/nature12586 PMid:24025773

14. Ali N, Zirak B, Rodriguez RS, Pauli ML, Truong HA, Lai K, et al. Regulatory T Cells in Skin Facilitate Epithelial Stem Cell Differentiation. Cell. 2017; 169(6):1119-1129. https://doi.org/10.1016/j.cell.2017.05.002 PMid:28552347 PMCid:PMC5504703

15. Alcorta DA, Xiong Y, Phelps D, Hannon G, Beach D, Barrett JC. Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts. PNUS USA. 1996; 93(24):13742-13747. https://doi.org/10.1073/pnas.93.24.13742 PMid:8943005 PMCid:PMC19411

16. Amirkhani MA, Shoae-Hassani A, Soleimani M, Hejazi S, Ghalichi L, Nilforoushzadeh MA. Rejuvenation of facial skin and improvement in the dermal architecture by transplantation of autologous stromal vascular fraction: a clinical study. Bioimpacts. 2016; 6(3):149-154. https://doi.org/10.15171/bi.2016.21 PMid:27853678 PMCid:PMC5108987

17. Baroni Edo R, Biondo-Simões Mde L, Auersvald A, Auersvald LA, Montemor Netto MR, Ortolan MC, et al. Influence of aging on the quality of the skin of white women: the role of collagen. Acta Cir Bras. 2012; 27(10):736-40. https://doi.org/10.1590/S0102-86502012001000012 PMid:23033137

18. Beausejour CM, Campisi J. Balancing regeneration and cancer. Nature. 2006; 443(7110):404-405. https://doi.org/10.1038/nature05221 PMid:16957734

19. Blanpain С, Fuchs E. Epidermal stem cells of the skin. Annu Rev Cell Dev Biol. 2006; 22:33-373. https://doi.org/10.1146/annurev.cellbio.22.010305.104357 PMid:16824012 PMCid:PMC2405915

20. Blanpain C, Fuchs E. Epidermal homeostasis: a balancing act of stem cells in the skin. Nat Rev Mol Cell Biol. 2009; 10(3):207-17. https://doi.org/10.1038/nrm2636 PMid:19209183 PMCid:PMC2760218

21. Buonocore D, Lazzeretti A, Tocabens P, Nobile V, Cestone E, Santin G, et al. Resveratrol-procyanidin blend: nutraceutical and antiaging efficacy evaluated in a placebocontrolled, double-blind study. Clin Cosmet Investig Dermatol. 2012; 5:159-65. https://doi.org/10.2147/CCID.S36102 PMid:23071399 PMCid:PMC3469214

22. Campisi J. Senescent Cells, Tumor Suppression, and Organismal Aging: Good Citizens, Bad Neighbors. Cell. 2005; 120(4):513-522. https://doi.org/10.1016/j.cell.2005.02.003 PMid:15734683

23. Commo S, Gaillard O, Bernard BA. Human hair greying is linked to a specific depletion of hair follicle melanocytes affecting both the bulb and the outer root sheath. Br Jоurnal of Dermatology. 2004; 150(3):435-43. https://doi.org/10.1046/j.1365-2133.2004.05787.x PMid:15030325

24. Daley GQ. The promise and perils of stem cell therapeutics. Cell Stem Cell. 2012; 10:740-749. https://doi.org/10.1016/j.stem.2012.05.010 PMid:22704514 PMCid:PMC3629702

25. Dasgupta J, Kar S, Liu R, Joseph J, Kalyanaraman B, Remington SJ, et al. Reactive oxygen species control senescence-associated matrix metalloproteinase-1 through c-Jun-N-terminal kinase. J Cell Physiol. 2010; 225(1):52-62. https://doi.org/10.1002/jcp.22193 PMid:20648623 PMCid:PMC2913426

26. Doles J, Storer M, Cozzuto L, Roma G, Keyes WM. Age-associated inflammation inhibits epidermal stem cell function. Genes Dev. 2012; 26(19):2144-2153. https://doi.org/10.1101/gad.192294.112 PMid:22972935 PMCid:PMC3465736

27. Farage АM, Miller WK, Maibach IH. Textbook of Aging Skin. Springer. 2017. 2222 p. https://doi.org/10.1007/978-3-662-47398-6

28. Fenske NA, Lober CW. Structural and functional changes of normal aging skin. J Am Acad Dermat. 1986; 15(4):571-585. https://doi.org/10.1016/S0190-9622(86)70208-9

29. Fisher GJ, Varani J, Voorhees JJ. Looking older: Fibroblast collapse and therapeutic implications. Arch Dermatol. 2008; 144:666e672. https://doi.org/10.1001/archderm.144.5.666

30. Flores I, Blasco MA. The role of telomers and telomerase in stem cell aging. FEBS Lett. 2010; 584(17):3826-30. https://doi.org/10.1016/j.febslet.2010.07.042 PMid:20674573

31. Fuchs Е. Skin stem cells: rising to the surface. J Cell Biol. 2008; 180(2):273-284. https://doi.org/10.1083/jcb.200708185 PMid:18209104 PMCid:PMC2213592

32. Fujiwara H, Ferreira M, Donati G, Marciano DK, Linton JM, Sato Y, et al. The basement membrane of hair follicle stem cells is a muscle cell niche. Cell. 2011; 144(4):577-89. https://doi.org/10.1016/j.cell.2011.01.014 PMid:21335239 PMCid:PMC3056115

33. Ganceviciene R. Skin anti-aging strategies. Dermatoendocrinol. 2012; 4(3):308-319. https://doi.org/10.4161/derm.22804 PMCid:PMC3583892

34. Giangreco A, Qin M, Pintar JE, Watt FM. Epidermal stem cells are retained in vivo throughout skin aging. Aging Cell. 2008; 7:250-259. https://doi.org/10.1111/j.1474-9726.2008.00372.x PMid:18221414 PMCid:PMC2339763

35. Guasch G. The Epithelial Stem Cell Niche in Skin. Biology and Engineering of Stem Cell Niches. Academic Press. 2017; 127-143. https://doi.org/10.1016/B978-0-12-802734-9.00009-3

36. Chu GY, Chen YF, Chen HY, Chan MH, Gau CS, Weng SM. Stem cell therapy on skin: Mechanisms, recent advances and drug reviewing issues. J Food Drug Anal. 2018; 26(1):14-20. https://doi.org/10.1016/j.jfda.2017.10.004 PMid:29389549

37. Gonçalves GMS, Barros PP, da Silva GH, dos Santos EM, Minutti AF. Formulations containing curcumin or trans-resveratrol increase dermal thickness in rats submitted to chemical peeling. J Cosmet Dermatol Sci Appl. 2017; 7:14-26. https://doi.org/10.4236/jcdsa.2017.71002

38. Gonzales K, Fuchs E. Skin and its regenerative powers: an alliance between stem cells and their niche. Dev Cell. 2017; 43:387-401. https://doi.org/10.1016/j.devcel.2017.10.001 PMid:29161590 PMCid:PMC5797699

39. Herbig U, Ferreira M, Condel L, Carey D, Sedivy JM. Cellular senescence in aging primates. Science. 2006; 311(5765):1257. https://doi.org/10.1126/science.1122446 PMid:16456035

40. Hickson LJ, Langhi Prata LGP, Bobart SA, Evans TK, Giorgadze N, Hashmi SK, et al. Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease. EBioMedicine. 2019; 47:446-456. https://doi.org/10.1016/j.ebiom.2019.08.069 PMid:31542391 PMCid:PMC6796530

41. Jeong JH. Adipose stem cells and skin repair. Curr Stem Cell Res Ther. 2010; 5(2):137-40. https://doi.org/10.2174/157488810791268690 PMid:19941454

42. Kafi R, Kwak HS, Schumacher WE, Cho S, Hanft VN, Hamilton TA. Improvement of naturally aged skin with vitamin A (retinol). Arch Dermatol. 2007; 143:606-12. https://doi.org/10.1001/archderm.143.5.606 PMid:17515510

43. Kaya G, Rodriguez I, Jorcano JL, Vassalli P, Stamenkovic I. Selective suppression of CD44 in keratinocytes of mice bearing an antisense CD44 transgene driven by a tissuespecific promoter disrupts hyaluronate metabolism in the skin and impairs keratinocyte proliferation. Genes Dev. 1997; 11:996-1007. https://doi.org/10.1101/gad.11.8.996 PMid:9136928

44. Kaya G, Grand D, Hotz R, Augsburger E, Carraux P, Didierjean L, et. al. Upregulation of CD44 and hyaluronate synthases by topical retinoids in mouse skin. J Invest Dermatol. 2005; 124:284-287. https://doi.org/10.1111/j.0022-202X.2004.23579.x PMid:15654991

45. Kaya G, Tran C, Sorg O, Hotz R, Grand D, Carraux P, et al. Hyaluronate fragments reverse skin atrophy by a CD44-dependent mechanism. PLoS Med. 2006; 3:e493. https://doi.org/10.1371/journal.pmed.0030493 PMid:17177600 PMCid:PMC1702558

46. Kaya G, Saurat JH. Dermatoporosis: a chronic cutaneous insufficiency/fragility syndrome. Dermatology 2007; 215:284-294. https://doi.org/10.1159/000107621 PMid:17911985

47. Keyes BE, Segal JP, Heller E, Lien WH, Chang CY, Guo X. Nfatc1 orchestrates aging in hair follicle stem cells. PNUS USA. 2013; 110(51):E4950-9. https://doi.org/10.1073/pnas.1320301110 PMid:24282298 PMCid:PMC3870727

48. Khavkin J, Ellis DA. Aging skin: histology, physiology, and pathology. Facial Plast Surg Clin North Am. 2011; 19(2):229-34. https://doi.org/10.1016/j.fsc.2011.04.003 PMid:21763983

49. Kirkland JL, Tchkonia T. Cellular senescence: A translational perspective. EBioMedicine. 2017; 21:21-28. https://doi.org/10.1016/j.ebiom.2017.04.013 PMid:28416161 PMCid:PMC5514381

50. Kligman AM. Perspectives and problems in cutaneous gerontology. J Invest Dermatol. 1979; 73:39-46. https://doi.org/10.1111/1523-1747.ep12532758 PMid:156237

51. Lagoumtzi SM, Chondrogianni N. Senolytics and senomorphics: Natural and synthetic therapeutics in the treatment of aging and chronic diseases. Free Radic Biol Med. 2021; 171:169-190. https://doi.org/10.1016/j.freeradbiomed.2021.05.003 PMid:33989756

52. Lane SW, Williams DA, Watt FM. Modulating the stem cell niche for tissue regeneration. Nat Biotechnol. 2014; 32(8):795-803. https://doi.org/10.1038/nbt.2978 PMid:25093887 PMCid:PMC4422171

53. Waaijer M, Goldeck D, Gunn DA, van Heemst D, Westendorp R, Pawelec G, Maier AB. Are skin senescence and immunosenescence linked within individuals? Aging cell. 2019;18(4):12956. Available from: https://doi.org/10.1111/acel.12956 https://doi.org/10.1111/acel.12956 PMid:31062498 PMCid:PMC6612632

54. Nelson G, Wordsworth J, Wang C, Jurk D, Lawless C, Martin-Ruiz C, et al. A senescent cell bystander effect: senescence-induced senescence. Aging Cell. 2012; 11:345-349. https://doi.org/10.1111/j.1474-9726.2012.00795.x PMid:22321662 PMCid:PMC3488292

55. Matsumura H, Mohri Y, Binh NT, Morinaga H, Fukuda M, Ito M, et al. Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis. Science. 2016; 351(6273):aad4395. https://doi.org/10.1126/science.aad4395 PMid:26912707

56. Mohiuddin АK. Skin Aging & Modern Age Anti-aging Strategies. GJMR: B Pharma, Drug Discovery, Toxicology & Medicine. 2019; 19(2). Version 1.0. https://doi.org/10.17352/ebook10113

57. Park BS, Jang AK, Sung HJ, Park SJ, Kwon HY. Adipose-Derived Stem Cells and their secretory factors as a promising therapy for skin aging. Dermatol Surg. 2008; 34:1323-1326. https://doi.org/10.1111/j.1524-4725.2008.34283.x PMid:18616537

58. Perez-Meza D, ZieringC, Sforza M, Krishnan G, Ball E, Daniels E. Hair follicle growth by stromal vascular fraction-enhanced adipose transplantation in baldness. Stem Cells Cloning. 2017; 10:1-10. https://doi.org/10.2147/SCCAA.S131431 PMid:28740409 PMCid:PMC5506773

59. Rando TA. Stem cells, ageing and the quest for immortality. Nature. 2006; 41(7097):1080-1086. https://doi.org/10.1038/nature04958 PMid:16810243

60. Ressler S, Bartkova J, Niederegger H, Bartek J, Scharffetter-Kochanek K, Jansen-Durr P, et al. p16INK4A is a robust in vivo biomarker of cellular aging in human skin. Aging Cell. 2006; 5:379-389. https://doi.org/10.1111/j.1474-9726.2006.00231.x PMid:16911562

61. Rittié L, Fisher G.. Natural and sun-induced aging of human skin. Cold Spring Harb Perspect Med. 2015; 5(1):1-14. https://doi.org/10.1101/cshperspect.a015370 PMid:25561721 PMCid:PMC4292080

62. Quan T, Fisher GJ. Role of Age-Associated Alterations of the Dermal Extracellular Matrix Microenvironment in Human Skin Aging: A Mini-Review. Gerontology. 2015; 61(5):427-34. https://doi.org/10.1159/000371708 PMid:25660807 PMCid:PMC4524793

63. Quan T. Molecular mechanisms of skin aging and age-related diseases. CRC Press. 2016. 326 p. https://doi.org/10.1201/b21370

64. Schofield R. The relationship between the spleen colony-forming cell and the haemopoietic stem cell. Blood Cells. 1978; 4(1-2):7-25.

65. Seyfarth F, Schliemann S, Antonov D, Elsner P. Dry skin, barrier function, and irritant contact dermatitis in the elderly. Clin Dermatol. 2011; 29(1):31-36. https://doi.org/10.1016/j.clindermatol.2010.07.004 PMid:21146729

66. Mane S, Vinchurkar K, Khan M, Sainy J, Nirmal S, Singh R, et al. Skin Anti-Ageing Strategies: A Review. Int J Eng Technol. 2019; 4(7):255-263. https://doi.org/10.33564/IJEAST.2019.v04i07.044

67. Simpson RM, Wells A, Thomas D, Stephens P, Steadman R, Phillips A. Aging fibroblasts resist phenotypic maturation because of impaired hyaluronan-dependent CD44/epidermal growth factor receptor signaling. Am J Pathol. 2010; 176(3):1215-1228. https://doi.org/10.2353/ajpath.2010.090802 PMid:20093489 PMCid:PMC2832144

68. Smith L. Histopathologic characteristics and ultrastructure of aging skin. Cutis. 1989; 43(5):414-24.

69. Strnadova К, Sandera V, Dvorankova B, Kodet O, Duskova M, Smetana K, et. al. Skin aging: the dermal perspective. Clinics in Dermatology. 2019; 37(4):326-335. https://doi.org/10.1016/j.clindermatol.2019.04.005 PMid:31345320

70. Taub AF, Pham K. Stem Cells in Dermatology and Anti-aging Care of the Skin. Facial Plast Surg Clin North Am. 2018; 26(4):425-437. https://doi.org/10.1016/j.fsc.2018.06.004 PMid:30213424

71. Thiers BH, Maize JC, Spicer SS, Cantor AB. The effect of aging and chronic sun exposure on human Langerhans cell populations. J Invest Dermatol. 1984; 82(3):223-226. https://doi.org/10.1111/1523-1747.ep12260055 PMid:6199432

72. Thompson MW, Aitken DA, van der Mei IA, Otahal P, Cicolini J, Winzenberg TM, et al. Predictors of Beagley-Gibson skin cast grade in older adults. Skin Res Technol. 2017; 23:235-242. https://doi.org/10.1111/srt.12328 PMid:27781312

73. Toma JG, McKenzie IA, Bagli D, Miller FD. Isolation and characterization of multipotent skin-derived precursors from human skin. Stem Cells. 2005; 23(6):727-37. https://doi.org/10.1634/stemcells.2004-0134 PMid:15917469

74. Tobin DJ. Introduction to skin aging. Journal of Tissue Viability. 2017; 26(1):37-44. https://doi.org/10.1016/j.jtv.2016.03.002 PMid:27020864

75. Zaki SM. Characteristics of the Skin of the Female Albino Rats in Different Ages: Histological, Morphometric and Electron Microscopic Study. J Cytol Histol. 2015; 3:004. https://doi.org/10.4172/2157-7099.S3-004

76. Zhu Y, Tchkonia T, Pirtskhalava T, Gower AC, Ding H, Giorgadze N, et al. The achilles’ heel of senescent cells: From transcriptome to senolytic drugs. Aging cell. 2015; 14(4):644-658. https://doi.org/10.1111/acel.12344 PMid:25754370 PMCid:PMC4531078

77. Zouboulis CC, Makrantonaki E. Clinical aspects and molecular diagnostics of skin aging. Clin Dermatol. 2011; 29(1):3-14. https://doi.org/10.1016/j.clindermatol.2010.07.001 PMid:21146726

78. Uitto J. The Role of elastin and collagen in cutaneous aging: intristic aging versus photoexposure. Journal of drug in dermatology. 2008; 8(2): 12-16.

79. Yamanishi Н, Fujiwara S, Soma T. Perivascular localization of dermal stem cells in human scalp. Exp Dermatol. 2012; 21(1):78-80. https://doi.org/10.1111/j.1600-0625.2011.01407.x PMid:22151396

80. Yang L, Peng R. Unveiling hair follicle stem cells. Stem Cell Reviews and Reports. 2010; 6(4): 658-664. https://doi.org/10.1007/s12015-010-9172-z PMid:20676942

81. Ge Y, Miao Y, Gur-Cohen S, Gomez N, Yang H, Nikolova M, et al. The aging skin microenvironment dictates stem cell behavior. PNUS USA. 2020; 117(10):5339-5350. https://doi.org/10.1073/pnas.1901720117 PMid:32094197 PMCid:PMC7071859

82. Yao Y, Cai J, Zhang P, Liao Y, Yuan Y, Dong Z, et al. Adipose Stromal Vascular Fraction Gel Grafting: A New Method for Tissue Volumization and Rejuvenation. Dermatol Surg. 2018; 44(10):1278-1286. https://doi.org/10.1097/DSS.0000000000001556 PMid:29781904

83. Varani J, Dame M, Rittie L, Fligiel S.E, Kang S, Fisher GJ, et al. Decreased collagen production in chronologically aged skin. Roles of age-dependent alteration in fibroblast function and defective mechanical stimulation. Am J Pathol. 2006; 168(6):1861-1868. https://doi.org/10.2353/ajpath.2006.051302 PMid:16723701 PMCid:PMC1606623

84. Victorelli S, Lagnado A, Halim J, Moore W, Talbot D, Barrett K, et al. Senescent human melanocytes drive skin ageing via paracrine telomere dysfunction. EMBO J. 2019; 38(23):e101982. https://doi.org/10.15252/embj.2019101982

85. Wahab A, Gao K, Jia C, Zhang F, Tian G, Murtaza G, et al. Significance of Resveratrol in Clinical Management of Chronic Diseases. Molecules. 2017; 22(8):1329. https://doi.org/10.3390/molecules22081329 PMid:28820474 PMCid:PMC6152193

86. Waller JM, Maibach HI. Age and skin structure and function, a quantitative approach (I): blood flow, pH, thickness, and ultrasound echogenicity. Skin Res Technol. 2005; 11(4):221-35. https://doi.org/10.1111/j.0909-725X.2005.00151.x PMid:16221138

87. Wang C, Jurk D, Maddick M, Nelson G, Martin-Ruiz C, von Zglinicki T. DNA damage response and cellular senescence in tissues of aging mice. Aging Cell. 2009; 8(3):311-23. https://doi.org/10.1111/j.1474-9726.2009.00481.x PMid:19627270

88. Wong VW, Levi B, Rajadas J, Longaker MT, Gurtner GC. Stem cell niches for skin regeneration. Int J Biomat. 2012. Available from: https://doi.org/10.1155/2012/926059 https://doi.org/10.1155/2012/926059 PMid:22701121 PMCid:PMC3371691

How to cite

Ivanishchev V. Current issues of skin aging and strategies for its correction. Cell Organ Transpl. 2021; 9(1):68-74. doi:10.22494/cot.v9i1.124

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